Collagen-Based Dermal Fillers: Past, Present, Future

ABSTRACT

The demand for dermal fillers and the variety of dermal fillers available have evolved dramatically during the past 2 decades. Collagen was the first material to be approved by the U.S. Food and Drug Administration (FDA) for injection into facial scars, furrows, and lines. Bovine collagen (95% type I and 5% type III collagen) was approved in 1981; buffered collagen Zyderm I and Zyderm II followed by Zyplast were FDA approved and released shortly thereafter. This article will focus on the historical benefits and risks of collagen injections and the typical outcomes. With the advent of hyaluronic acid products and other options, the risks of collagen and limited benefit have caused a marked loss of market share. Specifically, allergy is a major concern. As a result, two rounds of skin testing are required adding inconvenience and delay for both the practitioner and patient. Furthermore, a negative skin test does not guarantee allergic reactions or other more serious side effects will not occur. Finally, the perceived clinical efficacy is often short lived despite histopathologic assessments showing that collagen persists at best 9 months.

KEYWORDS

Collagen injectables - Zyderm - Zyplast - dermal fillers - liquid face-lift

REFERENCES

• 1 Baumann L, Kaufman J, Saghari S. Collagen fillers.  Dermatol Ther. 2006;  19 134-140
• 2 Klein A W. Skin filling: collagen and other injectables of the skin.  Dermatol Clin. 2001;  19 491-508
• 3 Cheng J T, Perkins S W, Hamilton M M. Collagen and injectable fillers.  Otolaryngol Clin North Am. 2002;  35 73-85
• 4 Fagien S. Facial soft-tissue augmentation with injectable autologous and allogenic human tissue collagen matrix (Autologen and Dermalogen).  Plast Reconstr Surg. 2000;  105 362-373 discussion 374-375
• 5 Klein A W. Implantation technics for injectable collagen. Two and one-half years of personal clinical experience.  J Am Acad Dermatol. 1983;  9 224-228
• 6 Eppley B L, Dadvand B. Injectable soft-tissue fillers: clinical overview.  Plast Reconstr Surg. 2006;  118 98e-106e
• 7 Johl S S, Burgett R A. Dermal filler agents: a practical review.  Curr Opin Ophthalmol. 2006;  17 471-479
• 8 Bauman L. CosmoDerm/CosmoPlast (human bioengineered collagen) for the aging face.  Facial Plast Surg. 2004;  20 125-128
• 9 Cohen S R, Berner C F, Busso M et al.. ArteFill: a long-lasting injectable wrinkle filler material—summary of the U.S. Food and Drug Administration trials and a progress report on 4- to 5-year outcomes.  Plast Reconstr Surg. 2006;  118(Suppl) 64S-76S
• 10 Lemperle G, Romano J J, Busso M. Soft tissue augmentation with Artecoll: 10-year history, indications, techniques, and complications.  Dermatol Surg. 2003;  29 573-587 discussion 587
• 11 Lowe N J, Maxwell C A, Patnaik R. Adverse reactions to dermal fillers.  Dermatol Surg. 2005;  31 1616-1625
• 12 Vedamurthy M. IADVL Dematosurgery Task Force . Standard guidelines for the use of dermal fillers.  Indian J Dermatol Venereol Leprol. 2008;  74(Suppl) S23-S27
• 13 Castrow II F F, Krull E A. Injectable collagen implant–update.  J Am Acad Dermatol. 1983;  9 889-893
• 14 Siegle R J, McCoy Jr J P, Schade W, Swanson N A. Intradermal implantation of collagen. Humoral immune responses associated with clinical reactions.  Arch Dermatol. 1984;  120 183-187
• 15 Glavas I P. Filling agents.  Ophthalmol Clin North Am. 2005;  18 249-257
• 16 Baumann L S, Kerdel F. The treatment of bovine collagen allergy with cyclosporin.  Dermatol Surg. 1999;  25 247-249
• 17 Mullins R J, Richards C, Walker T. Allergic reactions to oral, surgical and topical bovine collagen. Anaphylactic risk for surgeons.  Aust N Z J Ophthalmol. 1996;  24 257-260
• 18 Andre P, Lowe N J, Parc A. Adverse reactions to dermal fillers: a review of European experiences.  J Cosmet Laser Ther. 2005;  7 171-176
• 19 Pollack S. Some new injectable dermal filler materials: Hylaform^®, Restylane^® and Artecoll^® .  J Cutan Med Surg. 1999;  3(Suppl 4) S27-S35
• 20 Cohen J L. Understanding, avoiding, and managing dermal filler complications.  Dermatol Surg.. 2008;  34(Suppl 1) S92-S99
• 21 Zimmermann U S, Clerici T. The histological aspects of fillers complications.  Semin Cutan Med Surg. 2004;  23 241-250
• 22 Rapaport M J. Granuloma annulare caused by injectable collagen.  Arch Dermatol. 1984;  120 837-838
• 23 Alcalay J, Alkalay R, Gat A, Yorav S. Late-onset granulomatous reaction to Artecoll.  Dermatol Surg. 2003;  29 859-862
• 24 Fischer J, Metzler G, Schaller M. Cosmetic permanent fillers for soft tissue augmentation: a new contraindication for interferon therapies.  Arch Dermatol. 2007;  143 507-510
• 25 Sidwell R U, Johnson N, Francis N, Bunker C B. Cutaneous sarcoidal granulomas developing after Artecoll facial cosmetic filler in a patient with newly diagnosed systemic sarcoidosis.  Clin Exp Dermatol. 2006;  31 208-211
• 26 Hanke C W, Higley H R, Jolivette D M et al.. Abscess formation and local necrosis after treatment with Zyderm or Zyplast collagen implant.  J Am Acad Dermatol. 1991;  25 319-326
• 27 Glaich A S, Cohen J L, Goldberg L H. Injection necrosis of the glabella: protocol for prevention and treatment after use of dermal fillers.  Dermatol Surg. 2006;  32 276-281
• 28 Silva M T, Curi A L. Blindness and total ophthalmoplegia after aesthetic polymethylmethacrylate injection: case report.  Arq Neuropsiquiatr. 2004;  62 873-874
• 29 Sclafani A P, Romo T. Injectable fillers for facial soft tissue enhancement.  Facial Plast Surg. 2000;  16 29-34
• 30 Monstrey S J, Pitaru S, Hamdi M et al.. A two-stage phase 1 trial of evolence30 collagen for soft-tissue contour correction.  Plast Reconstr Surg. 2007;  120 303-311
• 31 Pitaru S, Noff M, Block L et al.. Long-term efficacy of a novel ribose-cross-linked collagen dermal filler: a histologic and histomorphometric study in an animal model.  Dermatol Surg. 2007;  33 1045-1054
• 32 Sadick N, Sorhaindo L. The utility of soft tissue fillers in clinical dermatology: treatment of fine wrinkles and skin defects.  Expert Rev Med Devices. 2007;  4 559-565
• 33 Sclafani A P, Romo T, Parker A et al.. Homologous collagen dispersion (Dermalogen) as a dermal filler: persistence and histology compared with bovine collagen.  Ann Plast Surg. 2002;  49 181-188
• 34 Cohen S R, Holmes R E. Artecoll: a long-lasting injectable wrinkle filler material: report of a controlled, randomized, multicenter clinical trial.  Plast Reconstr Surg. 2004;  114 964-976
• 35 Bergeret-Galley C. Comparison of resorbable soft tissue fillers.  Aesthet Surg J. 2004;  24 33-46
• 36 Sklar J A, White S M, Radiance F N. A new soft tissue filler.  Dermatol Surg. 2004;  30 764-768
• 37 Patel M P, Talmor M, Nolan W B. Botox and collagen for glabellar furrows: advantages of combination therapy.  Ann Plast Surg. 2004;  52 442-447
• 38 Ashinoff R. Overview: soft tissue augmentation.  Clin Plast Surg. 2000;  27 479-487
• 39 Cooperman L, Michaeli D. The immunogenicity of injectable collagen. I. A 1-year prospective study.  J Am Acad Dermatol. 1984;  10 638-646