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DOI: 10.1055/s-0029-1220706
© Georg Thieme Verlag KG Stuttgart · New York
Septins, a Novel Group of GTP-binding Proteins – Relevance in Hemostasis, Neuropathology and Oncogenesis
Septine, eine neue Gruppe GTP-bindender Proteine – Relevanz in Hämostase, Neuropathologie und OnkogenesePublikationsverlauf
Publikationsdatum:
12. Mai 2009 (online)
![](https://www.thieme-connect.de/media/klinpaed/200903/lookinside/thumbnails/10.1055-s-0029-1220706-1.jpg)
Abstract
Septins are a novel family of GTP-binding proteins which are essential for cytokinesis, vesicle trafficking, cytoskeletal reorganization and membrane dynamics. They are abundantly expressed in many mitotic cells. Interestingly, they are also expressed in non-dividing cells such as neurons and platelets in which they play an important role in exocytosis. Platelets from SEPT5 knockout mice show an enhanced serotonin secretion and platelet aggregation in response to subthreshold levels of agonists. Septins are associated with a wide array of critical biological events such as neoplasia, neurodegenerative diseases, infections and exocytosis. The role of septins in oncogenesis is complex. Increased expression of some septins seems to trigger the growth of tumor cells. However, other septin isoforms are shown to promote apoptosis and function as tumor suppressor proteins. Interestingly, septins form complexes consisting of multiple septin polypeptides and assemble into filaments and ring-like, higher-order structures. The different septins and their various isoforms seem to determine the function of the septin complex.
Zusammenfassung
Septine bilden eine neue Familie GTP-bindender Proteine, die für Zytokinese, intrazellulären Vesikeltransport, Organisation des Zytoskeletts und Membranveränderungen essentiell sind. Sie werden in vielen sich schnell-teilenden Zellen wie auch in sich nicht-teilenden Zellen exprimiert und sind hier für die Exozytose wichtig. Septine sind in vielfältige wichtige zellbiologische Prozesse involviert wie z.B. Onkogenese, neurodegenerative Erkrankungen, Infektionen und Exozytose. Die Rolle der Septine in der Onkogenese ist komplex. Erhöhte Expression einiger Septine scheint das Tumorwachstum zu triggern. Jedoch fördern andere Septin-Isoformen die Apoptose und funktionieren als Tumorsuppressor-Proteine. Interessant ist, dass Septine Komplexe bilden, die aus mehreren Septinproteinen bestehen und die dann wiederum Filamente oder ringähnliche Strukturen bilden. Die unterschiedlichen Septine und ihre Isoformen scheinen die Funktion der verschiedenen Septinkomplexe zu bestimmen.
Key words
septins - GTP-binding proteins - hemostasis - platelets - neuropathology - oncogenesis
Schlüsselwörter
Septine - GTP-bindende Proteine - Hämostase - Thrombozyten - Neuropathologie - Onkogenese
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Correspondence
Dr. K. Sandrock
University Hospital Freiburg
Department of Pediatrics and Adolescent Medicine
Mathildenstr.1
79106 Freiburg i. Br.
Germany
Telefon: +49/761/270 71 93
Fax: +49/761/270 45 82
eMail: kirstin.sandrock@uniklinik-freiburg.de