Z Gastroenterol 2009; 47 - A63
DOI: 10.1055/s-0029-1224042

Celiac disease and risk of subsequent type 1 diabetes

É Micskey 1, P Pánczél 2, L Blatniczky 1, K Lukács 3
  • 1Fővárosi Önkormányzat Szent János Kórháza és Északbudai Egyesített Kórházai, Budai Gyermekkórház Telephely, Budapest
  • 2Semmelweis Egyetem III. Belgyógyászati Klinika, III. Belosztály, Budapest
  • 3Semmelweis Egyetem, Cellscreen Alkalmazott Kutatási központ, Immungenomikai Laboratóium, Budapest

Earlier studies suggest that children with type 1 diabetes (T1D) are more likely to have a subsequent diagnosis of celiac disease. However, research is sparse on the risk of subsequent T1D in the population with celiac disease.

Aim: to determine the risk of subsequent T1D in children, adolescents and their first grade relatives.

Patients and methods: We have determined in celiac patients (n:61) and their asymptomatic family members (n: 128) the islet cell antibody (ICA/JDFU with indirect immune-fluorescence assay), glutamic acid decarboxylase autoantibody (GADA/U/ml, RIA) C-peptide (ng/ml, RIA) levels and the occurrence of the gene protein tyrosine phosphatase, non-receptor type 22 (PTPN22, TaqMan® SNP Genotyping Assay).

Results: We have found 2 elevated ICA levels (>10 JDFU) in the celiac group and one in the family members under 10 years, 1 elevated (<10 years) and 14 (>10 years) results in the control groups. Their iv. glucose challenge has proven an exact early insulin response. The other assays didn't prove any alterations. The PTPN22 polymorphism was equal to that in the normal occurrence.

Conclusion: Our celiac patients following a careful gluten free diet regimen have not shown a marked risk for subsequent type 1 diabetes mellitus.