Effectiveness of Intramuscular Aripiprazole Injection in Patients with Catatonia: Report on Three Cases

In the recent literature, orally administered aripiprazole, a second generation antipsychotic, was demonstrated to be effective in the resolution of catatonia. Our present paper is the first report of three cases of catatonia where intramuscularly administered high doses of aripiprazole were found to be effective in resolving severe catatonic states, independent of the features, or of the origin of catatonia, presenting either in schizophrenia or in major depression. On the basis of the unique mechanism of action of the drug and based on our clinical experience, we recommend the use of high doses of intramuscular aripiprazole as an alternative treatment for catatonia, when benzodiazepines or electroconvulsive therapy are not effective or not proposed.

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