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DOI: 10.1055/s-0029-1224200
© Georg Thieme Verlag KG Stuttgart · New York
Tumor Size of Conn's Adenoma and Comorbidities
Publication History
received 31.03.2009
accepted 12.05.2009
Publication Date:
22 June 2009 (online)
![](https://www.thieme-connect.de/media/hmr/200910/lookinside/thumbnails/10.1055-s-0029-1224200-1.jpg)
Abstract
Primary aldosteronism (PA) is associated with vascular end organ damage. The aim of the study was to evaluate differences regarding comorbidities depending on tumor size in patients with aldosterone producing adenoma (APA). The retrospective cross-sectional study was done by collection from 6 German centers (German Conn's registry) between 1990 and 2007. Among the 640 registered patients with PA, 60 operated patients with APA were analyzed. The main outcome of measures was the comorbidities depending on tumor size. Thirty-one patients (17 men, 14 women) had an adenoma size <20 mm, and 29 patients (10 men, 19 women) had an adenoma size≥20 mm. There was no difference in age, preoperative potassium, aldosterone, or creatinine levels, preoperative systolic and diastolic blood pressure, or duration of hypertension between the two groups. In the group with APA <20 mm, cerebrovascular events occurred with a prevalence of 12.9%, cardiac events 16.1%, peripheral vascular events 25.8%, renal insufficiency 16.1%, and sleep apnea 6.4%, respectively. There was no significant difference in comorbidities compared to the group with APA≥20 mm. Subgroup analysis (n=22) of follow-up data on post-operative systolic and diastolic blood pressure showed no significant difference between these subgroups with regard to potassium, aldosterone or creatinine levels, blood pressure, duration of hypertension, or comorbidities. Our data indicate a high prevalence of comorbidities in patients with APA. However, adenoma size was not correlated with cardio- and cerebrovascular comorbidities, and does not seem to be a prognostic factor for blood pressure outcome.
Key words
hyperaldosteronism - APA size - cerebrovascular and cardiac comorbidity - adrenal tumor size
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Correspondence
Dr. M. QuinklerMD
Clinical Endocrinology
Internal Medicine
Centre for Gastroenterology Hepatology and Endocrinology
Charité Campus Mitte
Charité University Medicine Berlin
Charitéplatz 1
10117 Berlin
Germany
Phone: +49/30/45051 4152
Fax: +49/30/45051 4952
Email: marcus.quinkler@charite.de