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Handchir Mikrochir Plast Chir 2009; 41(4): 217-223
DOI: 10.1055/s-0029-1234062
Übersichtsarbeit

© Georg Thieme Verlag KG Stuttgart · New York

Immunosuppression bei Handtransplantation: State of the Art, Zukunftsperspektiven

Immunosuppression in Hand Transplantation: State of the Art and Future PerspectivesR. Sucher 1 , T. Hautz 1 , G. Brandacher 1 , W. P. Andrew Lee 2 , R. Margreiter 1 , S. Schneeberger 1
  • 1Medizinische Universität Insbruck, Abteilung für Allgemein-, Transplantations- und Thoraxchirurgie, Innsbruck, Austria
  • 2Division of Plastic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Further Information

Publication History

eingereicht 8.4.2009

akzeptiert 2.7.2009

Publication Date:
17 August 2009 (online)

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Zusammenfassung

Die Minimierung der immunosuppressiven Therapie, stellt eine der größten Herausforderungen auf dem Gebiet der Transplantationsmedizin dar. Das dafür erforderliche Verständnis der molekularen Abläufe ist weiterhin Gegenstand intensiver Forschung. Dieser Review beschreibt den derzeitigen Stand des Wissens über akute Abstoßungsreaktionen von „Composite Tissue” Allotransplantaten und beleuchtet sowohl konventionelle als auch innovative Therapiemöglichkeiten.

Abstract

Avoidance or minimization of maintenance immunosuppression represents the key step for promoting wider applicability of reconstructive transplantation. Understanding the mechanisms of composite tissue allograft rejection is of essence in working towards this goal. We herein review the current knowledge on acute rejection in reconstructive transplantation and discuss findings in the light of novel immunosuppressive and immunomodulatory strategies.

Schlüsselwörter

Transplantationschirurgie - interdisziplinäre plastische Chirurgie - Handchirurgie - obere Extremität - Körperregion und Anatomie - Histologie

Key words

transplantation surgery - hand surgery - upper limb - histology

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Korrespondenzadresse

Dr. Robert Sucher

Medizinische Universität Insbruck

Abteilung für Allgemein

Transplantation und Thoraxchirurgie

Anichstraße 35

6020 Innsbruck

Österreich

Email: robert.sucher@i-med.ac.at