Planta Med 2009; 75 - SL31
DOI: 10.1055/s-0029-1234286

α-Mangostin, a major xanthone from Garcinia mangostana and other phenolic constituents, with potent antibacterial and analgesic activities

AA El-Gamal 1, 2, OA Basudan 1, AJ Al-Rehaily 1, MH Assaf 1, FM Abd El Halim 1, KH El Tahir 3
  • 1King Saud University, College of Pharmacy, Dept. of Pharmacognosy, P.O. box 2457, Riyadh 11451, KSA
  • 2Mansoura University, College of Pharmacy, Dept. of Pharmacognosy, El-Mansoura P.O. 35516 Egypt
  • 3King Saud University, College of Pharmacy, Dept. of Pharmacology, P.O. box 2457, Riyadh 11451, KSA

Genus Garcinia is rich in xanthones and prenylated phenolic compounds. Fruits of Garcinia mangostana, distributed in Southeast Asia have common folk uses like treatment of diarrhoea, anti-inflammatory and ulcers healing. It is a rich source of mangostin-type of xanthone with variety of biological activities. Repeated chromatographic separation and purification of the total alcohol extract of the pericarps of the titled fruits afforded six compounds identified as α-mangostin (1) β-mangostin (2), 1-hydroxy 3,6,7- trimethoxy 8-(3-methylbut-2-enyl)-xanthone (3), mangostanin (4), 1,6,7-trihydroxy 6',6'-dimethyl-2H-pyrano (2',3':3,4)-2,8-di(3-methylbut-2-enyl)xanthone (5) and catchin (6). Structural elucidation was achieved utilizing different spectroscopic techniques, including 1D and 2D NMR. α-Mangostin showed strong central and peripheral analgesic effects in addition to a potent antibacterial activity particularly against Bacillus subtilis and Staphylococcus aureus with MIC 1.6 and 3.2µg/ml, respectively.