RSS-Feed abonnieren
DOI: 10.1055/s-0029-1236165
© Thieme Medical Publishers
Sinonasal Undifferentiated Carcinoma: A 13-Year Experience at a Single Institution
Publikationsverlauf
Publikationsdatum:
22. September 2009 (online)
![](https://www.thieme-connect.de/media/sbs/201002/lookinside/thumbnails/10.1055-s-0029-1236165-1.jpg)
ABSTRACT
We present our experience with sinonasal undifferentiated carcinoma at the University of Michigan over 13 years and review prior published data. We conducted a retrospective review of 19 patients who presented to a tertiary care academic center multidisciplinary skull base clinic with sinonasal undifferentiated carcinoma between 1995 and 2008. Overall survival was 22% at 5 years, and the estimated 5-year distant metastasis-free survival was 35%. At 2 years, local control was 83%, regional control was 50%, and distant control was 83%. Local control was best in those patients treated nonsurgically, as was median survival, though this was not statistically significant. Nodal disease in the neck, either at presentation or at recurrence, was noted in 26% of patients. Survival for sinonasal undifferentiated carcinoma remains poor. It is possible that up-front radiation or chemoradiation will lead to better local control rates, though surgery remains a mainstay of treatment. In all cases, the cervical nodes should be addressed with primary treatment.
KEYWORDS
SNUC - sinonasal undifferentiated carcinoma - anterior skull base - subcranial
REFERENCES
- 1 Frierson Jr H F, Mills S E, Fechner R E, Taxy J B, Levine P A. Sinonasal undifferentiated carcinoma. An aggressive neoplasm derived from schneiderian epithelium and distinct from olfactory neuroblastoma. Am J Surg Pathol. 1986; 10 771-779
- 2 Gorelick J, Ross D, Marentette L, Blaivas M. Sinonasal undifferentiated carcinoma: case series and review of the literature. Neurosurgery. 2000; 47 750-754 discussion 754-755
- 3 Jones L R, Guffey P, Cordell K G et al.. Determination of tumor markers that can be used as prognostic indicators of sinonasal undifferentiated carcinoma, esthesioneuroblastoma and adenoid cystic carcinoma of the skull base. Data not yet published
- 4 Musy P Y, Reibel J F, Levine P A. Sinonasal undifferentiated carcinoma: the search for a better outcome. Laryngoscope. 2002; 112(8 Pt 1) 1450-1455
- 5 Chen A M, Daly M E, El-Sayed I et al.. Patterns of failure after combined-modality approaches incorporating radiotherapy for sinonasal undifferentiated carcinoma of the head and neck. Int J Radiat Oncol Biol Phys. 2008; 70 338-343
- 6 Rosenthal D I, Barker Jr J L, El-Naggar A K et al.. Sinonasal malignancies with neuroendocrine differentiation: patterns of failure according to histologic phenotype. Cancer. 2004; 101 2567-2573
- 7 Tanzler E D, Morris C G, Orlando C A, Werning J W, Mendenhall W M. Management of sinonasal undifferentiated carcinoma. Head Neck. 2008; 30 595-599
- 8 Kim B S, Vongtama R, Juillard G. Sinonasal undifferentiated carcinoma: case series and literature review. Am J Otolaryngol. 2004; 25 162-166
- 9 Rischin D, Porceddu S, Peters L, Martin J, Corry J, Weih L. Promising results with chemoradiation in patients with sinonasal undifferentiated carcinoma. Head Neck. 2004; 26 435-441
- 10 Miyamoto R C, Gleich L L, Biddinger P W, Gluckman J L. Esthesioneuroblastoma and sinonasal undifferentiated carcinoma: impact of histological grading and clinical staging on survival and prognosis. Laryngoscope. 2000; 110 1262-1265
Erin M LinM.D.
Clinical Lecturer, Department of Otolaryngology–Head and Neck Surgery
University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109
eMail: elmk@med.umich.edu