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Planta Med 2010; 76(7): 708-712
DOI: 10.1055/s-0029-1240627
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxicity of Natural Compounds Isolated from the Seeds of Garcinia afzelii

Alain Meli Lannang1 , 2 , Gabin Nselapi Louh3 , Bernadette Messi Biloa3 , Justin Komguem3 , Celine Djama Mbazoa3 , Beiban Luc Sondengam3 , Lieve Naesens4 , Christophe Pannecouque4 , Erik De Clercq4 , El H. Sayed El Ashry2
  • 1Department of Chemistry, Higher Teachers' Training College, University of Maroua, Maroua, Cameroon
  • 2Department of Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt
  • 3Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon
  • 4Rega Institute for Medical Research, Leuven, Belgium
Further Information

Publication History

received June 3, 2009 revised October 23, 2009

accepted October 29, 2009

Publication Date:
20 November 2009 (online)

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Abstract

The new compounds guttiferone O (1) and 3-methoxycheffouxanthone (2) have been isolated from the seeds of Garcinia afzelii Engl., together with nine known compounds: 2-hydroxy-1,7-dimethoxyxanthone (3), smeathxanthone A (4), 1,5-dihydroxyxanthone (5), 1,6-dihydroxy-5-methoxyxanthone (6), cheffouxanthone (7), 1,3,5-trihydroxyxanthone (8), smeathxanthone B (9), isoxanthochymol (10) and guttiferone E (11). Their structures were elucidated by means of 1D and 2D‐NMR techniques. All the isolates showed high cytotoxic activity and were found inactive when tested against HIV and influenza viruses.

Key words

Garcinia afzelii - Guttiferae - benzopyrones - xanthones - antiviral studies - cytotoxicity

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Prof. El-Sayed H. El-Ashry

Department of Chemistry
Faculty of Science
Alexandria University

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21321 Alexandria

Egypt

Phone: + 20 34 24 66 01

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