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Planta Med 2010; 76(7): 705-707
DOI: 10.1055/s-0029-1240681
Pharmacology
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic and Anti-infective Sesquiterpenes Present in Plagiochila disticha (Plagiochilaceae) and Ambrosia peruviana (Asteraceae)

José C. Aponte1 , Han Yang1 , Abraham J. Vaisberg2 , Denis Castillo2 , Edith Málaga2 , Manuela Verástegui2 , Lavona K. Casson3 , Nicole Stivers3 , Paula J. Bates3 , Rosario Rojas4 , Irma Fernandez4 , Walter H. Lewis5 , César Sarasara6 , Michel Sauvain7 , Robert H. Gilman8 , Gerald B. Hammond1
  • 1Department of Chemistry, University of Louisville, Louisville, KY, USA
  • 2Departamento de Microbiología y Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
  • 3James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
  • 4Departamento de Ciencias Farmacéuticas y Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
  • 5Department of Biology, Washington University, St. Louis, MO, USA
  • 6Confederacion de Nacionalidades Amazónicas del Perú, Lima, Perú
  • 7Université de Toulouse III, UMR 152 Mission IRD, Toulouse, France
  • 8Johns Hopkins School of Public Health, Baltimore, MD, USA
Further Information

Publication History

received September 25, 2009 revised November 8, 2009

accepted November 12, 2009

Publication Date:
03 December 2009 (online)

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Erratum for: Cytotoxic and Anti-infective Sesquiterpenes Present in Plagiochila disticha (Plagiochilaceae) and Ambrosia peruviana (Asteraceae)Planta Med 2010; 76(07): E1-E1
DOI: 10.1055/s-0029-1240802

Abstract

A pharmacological screening of the ethanol extract and fractions of two Peruvian medicinal plants, Plagiochila disticha and Ambrosia peruviana, led to the isolation and characterization of three ent-2,3-secoaromadendrane-type sesquiterpenoids, named plagiochiline A (1), I (2), and R (3), as well as of two pseudoguaianolids, damsin (4) and confertin (5), which exhibited significant cytotoxic activity against a panel of human tumor cell lines. Compounds 1, 4, and 5 were also investigated for their in vitro antileishmanial, trypanocidal, and antituberculosis activity against Leishmania amazonensis axenic amastigotes and Trypanosoma cruzi trypomastigotes, as well as against MDR and sensitive strains of Mycobacterium tuberculosis, respectively.

Supporting information available online at http://www.thieme-connect.de/ejournals/toc/plantamedica

Key words

Plagiochila disticha - Plagiochilaceae - Ambrosia peruviana - Asteraceae - antileishmania - trypanoside - tuberculosis - cytotoxic

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Univ.-Prof. Dr. Gerald Hammond

Department of Chemistry
University of Louisville

2320 S. Brook Street

Louisville, KY 40292

USA

Phone: + 1 50 28 52 59 98

Fax: + 1 50 28 52 38 99

Email: gb.hammond@louisville.edu

    www.thieme-connect.de/ejournals/toc/plantamedica