Planta Med 2010; 76(7): 721-725
DOI: 10.1055/s-0029-1240683
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Anti-HIV‐1 Diterpenoids from Leaves and Twigs of Polyalthia sclerophylla

Siriporn Saepou1 , Manat Pohmakotr1 , Vichai Reutrakul1 , Chalobon Yoosook2 , Jitra Kasisit2 , Chanita Napaswad2 , Patoomratana Tuchinda1
  • 1Department of Chemistry and Center for Innovation in Chemistry (PERCH‐CIC), Faculty of Science, Mahidol University, Bangkok, Thailand
  • 2Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand
Further Information

Publication History

received July 15, 2009 revised November 7, 2009

accepted November 12, 2009

Publication Date:
14 December 2009 (online)

Abstract

Bioassay-guided fractionation and purification of the anti-HIV-1-active MeOH extract from the leaves and twigs of Polyalthia sclerophylla led to the isolation of two new compounds, ent-kaur-sclerodimer (1) and cyclotucanol 3-palmitate (2), along with the known ent-kaur-16-en-19-oic acid (3), 15β-hydroxy-ent-kaur-16-en-19-oic acid (4), 15β-acetoxy-ent-kaur-16-en-19-oic acid (5), 15-oxo-ent-kaur-16-en-19-oic acid (6), 16α,17-dihydroxy-ent-kauran-19-oic acid (7), 16α-hydroxy-ent-kauran-19-oic acid (xylopic acid) (8), a pseudodimer (15α-hydroxy-ent-kaur-16-en-19-oic acid/17-hydroxy-ent-kaur-15-en-19-oic acid) (9), ermanin, nicotiflorin, and allantoin. Among these isolates, compound 3 was the most active in both anti-syncytium (EC50 13.7 µg/mL and selectivity index 3.1) and HIV-1 reverse transcriptase (IC50 34.1 µg/mL) assays.

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Dr. Patoomratana Tuchinda

Department of Chemistry
Faculty of Science
Mahidol University

Rama 6 Road

Bangkok 10400

Thailand

Phone: + 66 22 01 51 59

Fax: + 66 23 54 71 51

Email: scptc@mahidol.ac.th