Abstract
Patients with thymoma associated with pure red cell aplasia (PRCA) are rare and the
relevant literature is limited. Prognostic evaluations into the appropriate surgical
management of this rare coincidence of diseases are controversial, with some authors
believing that none of their cases experienced remission of anemia after thymectomy.
Despite the extreme rare concomitance of thymoma and PRCA, we report three consecutive
cases, who experienced long-term complete remission of PRCA after extended thymectomy
as their only therapy over a 6-year period. Possible features leading to the favorable
outcome are discussed.
Key words
Thymoma - pure red cell aplasia - thymectomy
References
- 1
Charles R J, Sabo K M, Kidd P G, Abkowitz J L.
The pathophysiology of pure red cell aplasia: implications for therapy.
Blood.
1996;
87 (11)
4831-4838
- 2
Murakawa T, Nakajima J, Sato H, Tanaka M, Takamoto S, Fukayama M.
Thymoma associated with pure red-cell aplasia: clinical features and prognosis.
Asian Cardiovasc Thorac Ann.
2002;
10 (2)
150-154
- 3
Fujisao S, Tsuda H.
Th1/Th2 balance alteration in the clinical course of a patient with pure red cell
aplasia and thymoma.
Br J Haematol.
1998;
103 (2)
308-310
- 4
Masaoka A, Hashimoto T, Shibata K, Yamakawa Y, Nakamae K, Iizuka M.
Thymomas associated with pure red cell aplasia. Histologic and follow-up studies.
Cancer.
1989;
64 (9)
1872-1878
- 5
Ritchie D S, Underhill C, Grigg A P.
Aplastic anemia as a late complication of thymoma in remission.
Eur J Haematol.
2002;
68 (6)
389-391
- 6
Mizobuchi S, Yamashiro T, Nonami Y et al.
Pure red cell aplasia and myasthenia gravis with thymoma: a case report and review
of the literature.
Jpn J Clin Oncol.
1998;
28 (11)
696-701
- 7
Thompson C A, Steensma D P.
Pure red cell aplasia associated with thymoma: clinical insights from a 50-year single-institution
experience.
Br J Haematol.
2006;
135 (3)
405-407
- 8
Bhargava R, Dolai T K, Singhal D et al.
Pure red cell aplasia associated with thymoma: Is thymectomy the cure?.
Leuk Res.
2009;
33 (3)
e17-e18
Dr. Ming Wu
Department of Cardiothoracic Surgery
2nd Affiliated Hospital, School of Medicine, Zhejiang University
88# Jiefang Street
Hangzhou 310009
China
Telefon: + 86 5 71 87 78 36 41
Fax: + 86 5 71 87 78 36 88
eMail: iwuming@hotmail.com
