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Planta Med 2010; 76(10): 1022-1025
DOI: 10.1055/s-0029-1240896
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Bioactive Steroidal Alkaloids from Sarcococca hookeriana

Krishna Prasad Devkota1 , 2 , Jean D. Wansi2 , Bruno N. Lenta2 , Samreen Khan3 , Muhammad I. Choudhary3 , Norbert Sewald2
  • 1Institute of Forestry, Pokhara Campus, Tribhuvan University, Pokhara, Kaski, Nepal
  • 2Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, Bielefeld, Germany
  • 3H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
Further Information

Publication History

received July 10, 2009 revised January 21, 2010

accepted January 25, 2010

Publication Date:
25 February 2010 (online)

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Abstract

Four new 5α-pregnane-type steroidal alkaloids, hookerianamides L (1), M (2), N (3), and O (4), and a known N-formylchonemorphine (5) have been isolated by acid-base extraction of the dichloromethane extract of Sarcococca hookeriana. The structures of all compounds were determined with spectroscopic techniques and by comparison with literature data. All compounds displayed antileishmanial and antibacterial properties. Compounds 1, 4, and 5 were found to be more potent than standard pentamidine (IC50 = 9.59 µg/mL) with respect to leishmanicidal activity. The minimum inhibitory concentration of most of the compounds against Bacillus subtilis, Streptococcus minor, and Streptococcus ferus was lower than that of the standard ampicillin.

Key words

Buxaceae - Sarcococca hookeriana - steroidal alkaloids - antileishmanial - antibacterial

References

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Dr. Krishna Prasad Devkota

Institute of Forestry
Pokhara Campus
Tribhuvan University

P. O. Box 43

Pokhara

Kaski 33700

Nepal

Phone: + 97 7 61 43 21 69

Fax: + 97 7 61 43 15 63

Email: devkotakpd@yahoo.com

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