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Planta Med 2010; 76(10): 1007-1010
DOI: 10.1055/s-0029-1240911
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Chemical Constituents of Alnus firma and Their Inhibitory Activity on Lipopolysaccharide-Induced Nitric Oxide Production in BV2 Microglia

Min A. Lee1 , Hee Kyoung Lee2 , Seung Hyun Kim2 , Young Choong Kim1 , Sang Hyun Sung1
  • 1College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Korea
  • 2Institute for Life Science, ElcomScience Co., Ltd., Seoul, Korea
Further Information

Publication History

received October 16, 2009 revised January 13, 2010

accepted January 19, 2010

Publication Date:
01 March 2010 (online)

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Erratum for: Chemical Constituents of Alnus firma and Their Inhibitory Activity on Lipopolysaccharide-Induced Nitric Oxide Production in BV2 MicrogliaPlanta Med 2010; 76(10): E3-E3
DOI: 10.1055/s-0030-1249808

Abstract

A methanolic extract of Alnus firma barks (Betulaceae) significantly attenuated nitric oxide production in lipopolysaccharide-stimulated BV2 microglia. Two new compounds, characterized as 4-hydroxy-2,6-dimethoxyphenyl 6′-O-syringoyl-β-D-glucopyranoside (1) and 4-hydroxy-2,6-dimethoxyphenyl 6′-O-vanilloyl-β-D-glucopyranoside (2), were isolated from the barks of A. firma using bioactivity-guided fractionation, together with two known phenolic glycosides (3, 4) and 11 known diarylheptanoids (5–15). Among these compounds, 1–4 and 6–11 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells at concentrations ranging from 10 µM to 100 µM.

Key words

Alnus firma (Betulaceae) - phenolic glycosides - diarylheptanoids - nitric oxide - BV2 microglia - lipopolysaccharide

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Prof. Dr. Sang Hyun Sung

College of Pharmacy and Research Institute of Pharmaceutical Sciences
Seoul National University

599 Gwanak-ro

Gwanak-gu

Seoul 151–742

Korea

Phone: + 82 28 80 78 59

Fax: + 82 28 77 78 59

Email: shsung@snu.ac.kr

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