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DOI: 10.1055/s-0029-1241187
© Georg Thieme Verlag KG Stuttgart · New York
Efficacy of Continuous Acyclovir Infusion in Neonatal Herpes Virus Encephalitis
Publication History
received 28.07.2009
accepted 09.09.2009
Publication Date:
04 February 2010 (online)

Abstract
We have successfully eliminated herpes simplex virus-2 from the central nervous system in a case of neonatal herpes simplex virus encephalitis with a continuous acyclovir infusion. A male infant delivered from a healthy 22-year-old woman without genital or systemic herpes symptoms around delivery began to develop fever and intractable seizures. He was started on intermittent intravenous acyclovir (20 mg/kg every 8 h) based on the diagnosis of herpes encephalitis. The virus was not eliminated with intermittent acyclovir and vidarabine, while continuous acyclovir was ultimately effective in eliminating herpes simplex virus from his central nervous system. This report demonstrates the efficacy of continuous acyclovir infusion in neonatal herpes simplex virus encephalitis.
Key words
neonatal herpes encephalitis - continuous acyclovir infusion - herpes simplex virus-2
References
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Correspondence
Yosuke KakisakaMD
Department of Pediatrics
Tohoku University School of Medicine
1-1 Seiryo-Machi
Aobaku
Sendai
980-8574 Miyagi
Japan
Phone: +81/22/717 72 87
Fax: +81/22/717 72 90
Email: kakisuke@mui.biglobe.ne.jp