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DOI: 10.1055/s-0029-1241875
© Georg Thieme Verlag KG Stuttgart · New York
Evaluation of a Possible Inflammatory Response after Appendectomy for Non-Perforated Appendicitis in Children
Publication History
received September 04, 2009
accepted after revision September 06, 2009
Publication Date:
28 October 2009 (online)
![](https://www.thieme-connect.de/media/ejps/201001/lookinside/thumbnails/10.1055-s-0029-1241875-1.jpg)
Abstract
background: The inflammatory process in the post-appendectomy period is not well characterized. In a pilot study, we prospectively followed the kinetics of different inflammatory mediators before and after appendectomy in children, and compared the results of the groups open appendectomy (OA) and laparoscopic appendectomy (LA).
Material and Methods: Levels of sP-selectin, tPA, MCP-1, IL-6, IL-8, sVCAM-1, and sCD40L were measured before appendectomy and on the next three consecutive days in the serum of 25 children (16 males and 9 females) aged 7 – 16 years (mean 12.6±2.47 years) with non-perforated acute appendicitis.
Results: LA and OA were performed in 16 and 9 patients respectively. None of the markers of inflammation differed significantly by surgical approach at any point of observation. However, sP-selectin, MCP-1 and sVCAM-1 levels were found to have significantly different postoperative kinetics with a trend towards higher values in the laparoscopic group compared to the open appendectomy group (p=0.034, p=0.016 and p=0.025, respectively).
Conclusions: The cytokines sP-selectin, MCP-1 and sVCAM-1 may play a role in the possible post-appendectomy cytokine activation after non-perforated appendicitis. Since this phenomenon is more evident after LA than after OA, the contribution of the different LA procedures has to be further investigated.
Key words
appendicitis - children - cytokines - inflammation - laparoscopic appendectomy
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Correspondence
Dr. Francis SerourMD
The E. Wolfson Medical center
Department of Pediatric Surgery
62 Halokhamim Street
58100 Holon
Israel
Phone: +97/235/02 84 19
Fax: +97/235/02 81 86
Email: serour@wolfson.health.gov.il