Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk Factors

ABSTRACT

In this article, the incidence, mortality, and survival rates for colorectal cancer are reviewed, with attention paid to regional variations and changes over time. A concise overview of known risk factors associated with colorectal cancer is provided, including familial and hereditary factors, as well as environmental lifestyle-related risk factors such as physical inactivity, obesity, smoking, and alcohol consumption.

KEYWORDS

Colorectal cancer - epidemiology - incidence - survival - risk factors

REFERENCES

• 1 World Health Organization .Cancer Incidence in Five Continents. Lyon; The World Health Organization and The International Agency for Research on Cancer 2002
• 2 World Cancer Research Fund and American Institute for Cancer Research .Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective. Washington, DC; American Institute for Cancer Research 2007
• 3 Boyle P, Langman J S. ABC of colorectal cancer: Epidemiology.  BMJ. 2000;  321(7264) 805-808
• 4 Boyle P, Ferlay J. Mortality and survival in breast and colorectal cancer.  Nat Clin Pract Oncol. 2005;  2(9) 424-425
• 5 Parkin D, Bray F, Ferlay J. Global cancer statistics, 2002.  CA Cancer J Clin. 2006;  55 74-108
• 6 Ferlay J, Bray F, Pisani P, Parkin D M. GLOBOCAN 2002: Cancer incidence, mortality and prevalence worldwide. Lyon; International Agency for Research on Cancer 2004
• 7 U.S. Cancer Statistics Working Group .United States Cancer Statistics: 1999–2005 Incidence and Mortality Web-based Report. Atlanta, GA; U.S. Department of Health and Human Services, Centers for Disease Control and Prevention & National Cancer Institute 2009 http://Available at: www.cdc.gov/uscs Accessed October 21, 2009
• 8 Janout V, Kollárová H. Epidemiology of colorectal cancer.  Biomed Pap Med Fac Univ Palacku Olomouc Czech Repub. 2001;  145 5-10
• 9 Wilmink A BM. Overview of the epidemiology of colorectal cancer.  Dis Colon Rectum. 1997;  40(4) 483-493
• 10 Jemal A, Thun M J, Ries L A et al.. Annual report to the nation on the status of cancer, 1975-2005, featuring trends in lung cancer, tobacco use, and tobacco control.  J Natl Cancer Inst. 2008;  100(23) 1672-1694
• 11 Jemal A, Clegg L X, Ward E et al.. Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival.  Cancer. 2004;  101(1) 3-27
• 12 American Cancer Society .Cancer Facts & Figures for African Americans 2009–2010. Oklahoma City, OK; American Cancer Society; 2009 Available from: http://www.cancer.org/docroot/STT/stt_0.asp Accessed May 26, 2009
• 13 National Institutes of Health .What You Need To Know About Cancer of the Colon and Rectum. Bethesda, MD; U.S. Department of Health and Human Services & National Institutes of Health 2006
• 14 Fairley T L, Cardinez C J, Martin J et al.. Colorectal cancer in U.S. adults younger than 50 years of age, 1998-2001.  Cancer. 2006;  107(5, Suppl) 1153-1161
• 15 Labianca R, Beretta G D, Mosconi S, Milesi L, Pessi M A. Colorectal cancer: screening.  Ann Oncol. 2005;  16(Suppl 2) ii127-ii132
• 16 de Jong A E, Morreau H, Nagengast F M et al.. Prevalence of adenomas among young individuals at average risk for colorectal cancer.  Am J Gastroenterol. 2005;  100(1) 139-143
• 17 Ries L AG, Melbert D, Krapcho M et al.. SEER cancer statistics review, 1975–2005. 2008 Bethesda, MD;
• 18 Jackson-Thompson J, Ahmed F, German R R, Lai S M, Friedman C. Descriptive epidemiology of colorectal cancer in the United States, 1998-2001.  Cancer. 2006;  107(5, Suppl) 1103-1111
• 19 American Cancer Society .Colorectal Cancer Facts & Figures Special Edition 2005. Oklahoma City, OK; American Cancer Society; 2005 Available from: http://www.cancer.org/docroot/STT/stt_0.asp Accessed May 26, 2009
• 20 O'Connell J B, Maggard M A, Liu J H et al.. Rates of colon and rectal cancers are increasing in young adults.  Am Surg. 2003;  2003(69) 866-872
• 21 O'Connell J B, Maggard M A, Livingston E H, Yo C K. Colorectal cancer in the young.  Am J Surg. 2004;  187(3) 343-348
• 22 Davies R J, Miller R, Coleman N. Colorectal cancer screening: prospects for molecular stool analysis.  Nat Rev Cancer. 2005;  5 199-209
• 23 Grande M, Milito G, Attina G M et al.. Evaluation of clinical, laboratory and morphologic prognostic factors in colon cancer.  World J Surg Oncol. 2008;  6 98
• 24 Skibber J, Minsky B, Hoff P. Cancer of the colon and rectum. In: DeVita VT Jr, Hellmann S, Rosenberg SA Cancer: principles & practice of oncology. 6th ed. Philadelphia; Lippincott Williams & Wilkins 2001: 1216-1271
• 25 Boardman L A, Morlan B W, Rabe K G et al.. Colorectal cancer risks in relatives of young-onset cases: is risk the same across all first-degree relatives?.  Clin Gastroenterol Hepatol. 2007;  5(10) 1195-1198
• 26 Papadopoulos N, Nicolaides N C, Wei Y F et al.. Mutation of a mutL homolog in hereditary colon cancer.  Science. 1994;  263(5153) 1625-1629
• 27 Jeter J M, Kohlmann W, Gruber S B. Genetics of colorectal cancer.  Oncology. 2006;  20(3) 269-276
• 28 Al-Sukhni W, Aronson M, Gallinger S. Hereditary colorectal cancer syndromes: familial adenomatous polyposis and lynch syndrome.  Surg Clin North Am. 2008;  88(4) 819-844, vii
• 29 Lynch H T, Lynch J F, Lynch P M, Attard T. Hereditary colorectal cancer syndromes: molecular genetics, genetic counseling, diagnosis and management.  Fam Cancer. 2008;  7(1) 27-39
• 30 Johnson I T, Lund E K. Review article: nutrition, obesity and colorectal cancer.  Aliment Pharmacol Ther. 2007;  26(2) 161-181
• 31 Willett W C. Diet and cancer: an evolving picture.  JAMA. 2005;  293(2) 233-234
• 32 Larsson S C, Wolk A. Meat consumption and risk of colorectal cancer: a meta-analysis of prospective studies.  Int J Cancer. 2006;  119(11) 2657-2664
• 33 Santarelli R L, Pierre F, Corpet D E. Processed meat and colorectal cancer: a review of epidemiologic and experimental evidence.  Nutr Cancer. 2008;  60(2) 131-144
• 34 Kabat G C, Miller A B, Jain M, Rohan T E. A cohort study of dietary iron and heme iron intake and risk of colorectal cancer in women.  Br J Cancer. 2007;  97(1) 118-122
• 35 Sinha R. An epidemiologic approach to studying heterocyclic amines.  Mutat Res. 2002;  506–507 197-204
• 36 Lee K J, Inoue M, Otani T, Iwasaki M, Sasazuki S, Tsugane S. JPHC Study Group . Physical activity and risk of colorectal cancer in Japanese men and women: the Japan Public Health Center-based prospective study.  Cancer Causes Control. 2007;  18(2) 199-209
• 37 Bazensky I, Shoobridge-Moran C, Yoder L H. Colorectal cancer: an overview of the epidemiology, risk factors, symptoms, and screening guidelines.  Medsurg Nurs. 2007;  16(1) 46-51 quiz 52
• 38 Campbell P T, Cotterchio M, Dicks E, Parfrey P, Gallinger S, McLaughlin J R. Excess body weight and colorectal cancer risk in Canada: associations in subgroups of clinically defined familial risk of cancer.  Cancer Epidemiol Biomarkers Prev. 2007;  16(9) 1735-1744
• 39 Zisman A L, Nickolov A, Brand R E, Gorchow A, Roy H K. Associations between the age at diagnosis and location of colorectal cancer and the use of alcohol and tobacco: implications for screening.  Arch Intern Med. 2006;  166(6) 629-634
• 40 Botteri E, Iodice S, Raimondi S, Maisonneuve P, Lowenfels A B. Cigarette smoking and adenomatous polyps: a meta-analysis.  Gastroenterology. 2008;  134(2) 388-395; e3
• 41 Tsong W H, Koh W P, Yuan J M, Wang R, Sun C L, Yu M C. Cigarettes and alcohol in relation to colorectal cancer: the Singapore Chinese Health Study.  Br J Cancer. 2007;  96(5) 821-827
• 42 Pöschl G, Seitz H K. Alcohol and cancer.  Alcohol Alcohol. 2004;  39(3) 155-165