Unsuspected Triggers of Venous Thromboembolism—Trivial or Not So Trivial?

Giuseppe Lippi; Massimo Franchini; Emmanuel J Favaloro

doi:10.1055/s-0029-1242713

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2009; 35(7): 597-604
DOI: 10.1055/s-0029-1242713

Unsuspected Triggers of Venous Thromboembolism—Trivial or Not So Trivial?

Giuseppe Lippi¹ , Massimo Franchini² , Emmanuel J. Favaloro³

¹U.O. Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospadaliero-Universitaria di Parma, Parma, Italy
²Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliero-Universitaria di Parma, Italy
³Department of Haematology, Institute of Clinical Pathology and Medical Research (ICPMR), Westmead Hospital, Westmead, Australia

Abstract

ABSTRACT

Venous thromboembolism (VTE) can be considered a multifactorial disorder involving a variety of inherited and acquired prothrombotic conditions and events. Although greater emphasis has classically been given to traditional thrombophilic risk factors, there is increasing recognition of less typical precipitating conditions and events. Indeed, the list of plausible but unusual triggers of thrombosis includes sneezing and coughing attacks, eating, migraine, sexual intercourse, strenuous physical exercise, drug abuse, and defecation. Although it is difficult to assert conclusively the true contribution of such events to the etiology of acute episodes of venous thrombosis, it seems reasonable to conclude that the concomitant presence of such trivial elements with one or more additional risk factors for VTE might precipitate an acute thrombotic episode.

KEYWORDS

Deep vein thrombosis - pulmonary embolism - risk factor - thrombosis - trigger - venous thromboembolism

Full Text

References

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Giuseppe LippiM.D.

U.O. Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospadaliero-Universitaria di Parma, Strada Abbeveratoia

2, 43100 Parma, Italy

Email: giuseppe.lippi@univr.it

Email: ulippi@tin.it