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Semin Thromb Hemost 2009; 35(7): 665-670
DOI: 10.1055/s-0029-1242720
© Thieme Medical Publishers

Particulate Air Pollution and Cardiovascular Risk: Short-term and Long-term Effects

Massimo Franchini1 , Pier Mannuccio Mannucci2
  • 1Immunohematology and Transfusion Center, Department of Pathology and Laboratory Medicine, University Hospital of Parma, Italy
  • 2Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Medicine and Medical Specialties, University of Milan and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
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Publikationsdatum:
09. Dezember 2009 (online)

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ABSTRACT

It is well known that exposure to particulate air pollutants is associated with the development of adverse health effects. In particular, there is growing evidence of a close relationship between increased levels of environmental pollutants and cardiovascular disease. Particle exposure may trigger acute cardiac events as well as promote the chronic development of cardiovascular disorders. Several biological mechanisms have been suggested to explain the important effect of air pollution on cardiovascular morbidity and mortality, although the exact pathways are not fully understood. The literature data on the short-term and long-term cardiovascular effects of particulate air pollutants are discussed in this review from a clinical and mechanistic point of view.

KEYWORDS

Air pollution - thrombosis - cardiovascular disease

REFERENCES

  • 1 Brunekreef B, Holgate S T. Air pollution and health.  Lancet. 2002;  360(9341) 1233-1242
    CrossrefPubMedSuche in Google Scholar
  • 2 Brook R D, Franklin B, Cascio W Expert Panel on Population and Prevention Science of the American Heart Association et al. Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association.  Circulation. 2004;  109(21) 2655-2671
    CrossrefPubMedSuche in Google Scholar
  • 3 Franchini M, Mannucci P M. Short-term effects of air pollution on cardiovascular diseases: outcomes and mechanisms.  J Thromb Haemost. 2007;  5(11) 2169-2174
    CrossrefPubMedSuche in Google Scholar
  • 4 Schwarze P E, Ovrevik J, Låg M et al.. Particulate matter properties and health effects: consistency of epidemiological and toxicological studies.  Hum Exp Toxicol. 2006;  25(10) 559-579
    CrossrefPubMedSuche in Google Scholar
  • 5 Bhatnagar A. Environmental cardiology: studying mechanistic links between pollution and heart disease.  Circ Res. 2006;  99(7) 692-705
    CrossrefPubMedSuche in Google Scholar
  • 6 Brook R D. Cardiovascular effects of air pollution.  Clin Sci (Lond). 2008;  115(6) 175-187
    CrossrefPubMedSuche in Google Scholar
  • 7 Gurgueira S A, Lawrence J, Coull B, Murthy G GK, González-Flecha B. Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation.  Environ Health Perspect. 2002;  110(8) 749-755
    CrossrefPubMedSuche in Google Scholar
  • 8 Sharman J E, Coombes J S, Geraghty D P, Fraser D I. Exposure to automotive pollution increases plasma susceptibility to oxidation.  Arch Environ Health. 2002;  57(6) 536-540
    CrossrefPubMedSuche in Google Scholar
  • 9 Peters A, Fröhlich M, Döring A et al.. Particulate air pollution is associated with an acute phase response in men; results from the MONICA-Augsburg Study.  Eur Heart J. 2001;  22(14) 1198-1204
    CrossrefPubMedSuche in Google Scholar
  • 10 Fujii T, Hayashi S, Hogg J C et al.. Interaction of alveolar macrophages and airway epithelial cells following exposure to particulate matter produces mediators that stimulate the bone marrow.  Am J Respir Cell Mol Biol. 2002;  27(1) 34-41
    PubMedSuche in Google Scholar
  • 11 Donaldson K, Mills N, MacNee W, Robinson S, Newby D. Role of inflammation in cardiopulmonary health effects of PM.  Toxicol Appl Pharmacol. 2005;  207 483-488
    CrossrefPubMedSuche in Google Scholar
  • 12 Ghio A J, Kim C, Devlin R B. Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers.  Am J Resp Crit Care Med. 2000;  162 981-988
    PubMedSuche in Google Scholar
  • 13 Rückerl R, Phipps R P, Schneider A et al.. Ultrafine particles and platelet activation in patients with coronary heart disease—results from a prospective panel study.  Part Fibre Toxicol. 2007;  4 1
    CrossrefPubMedSuche in Google Scholar
  • 14 Rückerl R, Ibald-Mulli A, Koenig W et al.. Air pollution and markers of inflammation and coagulation in patients with coronary heart disease.  Am J Respir Crit Care Med. 2006;  173 432-441
    CrossrefPubMedSuche in Google Scholar
  • 15 Vermylen J, Hoylaerts M F. The procoagulant effects of air pollution.  J Thromb Haemost. 2007;  5(2) 250-251
    CrossrefPubMedSuche in Google Scholar
  • 16 Baccarelli A, Zanobetti A, Martinelli I et al.. Effects of exposure to air pollution on blood coagulation.  J Thromb Haemost. 2007;  5 252-260
    CrossrefPubMedSuche in Google Scholar
  • 17 Campen M J, Costa D L, Watkinson W P. Cardiac and thermoregulatory toxicity of residual oil fly ash in cardiopulmonary-compromised rats.  Inhal Toxicol. 2000;  12(suppl 2) 7-22
    PubMedSuche in Google Scholar
  • 18 Peters A, Perz S, Döring A, Stieber J, Koenig W, Wichmann H E. Increases in heart rate during an air pollution episode.  Am J Epidemiol. 1999;  150(10) 1094-1098
    PubMedSuche in Google Scholar
  • 19 Pope III C A, Verrier R L, Lovett E G et al.. Heart rate variability associated with particulate air pollution.  Am Heart J. 1999;  138(5 Pt 1) 890-899
    CrossrefPubMedSuche in Google Scholar
  • 20 Gold D R, Litonjua A, Schwartz J et al.. Ambient pollution and heart rate variability.  Circulation. 2000;  101(11) 1267-1273
    PubMedSuche in Google Scholar
  • 21 Liao D, Creason J, Shy C, Williams R, Watts R, Zweidinger R. Daily variation of particulate air pollution and poor cardiac autonomic control in the elderly.  Environ Health Perspect. 1999;  107(7) 521-525
    CrossrefPubMedSuche in Google Scholar
  • 22 Luttmann-Gibson H, Suh H H, Coull B A et al.. Short-term effects of air pollution on heart rate variability in senior adults in Steubenville, Ohio.  J Occup Environ Med. 2006;  48(8) 780-788
    PubMedSuche in Google Scholar
  • 23 Park S K, O'Neill M S, Vokonas P S, Sparrow D, Schwartz J. Effects of air pollution on heart rate variability: the VA normative aging study.  Environ Health Perspect. 2005;  113(3) 304-309
    CrossrefPubMedSuche in Google Scholar
  • 24 Schwartz J, Litonjua A, Suh H et al.. Traffic related pollution and heart rate variability in a panel of elderly subjects.  Thorax. 2005;  60(6) 455-461
    CrossrefPubMedSuche in Google Scholar
  • 25 Adar S D, Gold D R, Coull B A, Schwartz J, Stone P H, Suh H. Focused exposures to airborne traffic particles and heart rate variability in the elderly.  Epidemiology. 2007;  18(1) 95-103
    CrossrefPubMedSuche in Google Scholar
  • 26 Peters A, Liu E, Verrier R L et al.. Air pollution and incidence of cardiac arrhythmia.  Epidemiology. 2000;  11(1) 11-17
    CrossrefPubMedSuche in Google Scholar
  • 27 Rich D Q, Schwartz J, Mittleman M A et al.. Association of short-term ambient air pollution concentrations and ventricular arrhythmias.  Am J Epidemiol. 2005;  161(12) 1123-1132
    CrossrefPubMedSuche in Google Scholar
  • 28 Berger A, Zareba W, Schneider A et al.. Runs of ventricular and supraventricular tachycardia triggered by air pollution in patients with coronary heart disease.  J Occup Environ Med. 2006;  48(11) 1149-1158
    PubMedSuche in Google Scholar
  • 29 Ibald-Mulli A, Stieber J, Wichmann H E, Koenig W, Peters A. Effects of air pollution on blood pressure: a population-based approach.  Am J Public Health. 2001;  91(4) 571-577
    CrossrefPubMedSuche in Google Scholar
  • 30 Urch B, Silverman F, Corey P et al.. Acute blood pressure responses in healthy adults during controlled air pollution exposures.  Environ Health Perspect. 2005;  113(8) 1052-1055
    CrossrefPubMedSuche in Google Scholar
  • 31 Simkhovich B Z, Kleinman M T, Kloner R A, Kloner R A. Air pollution and cardiovascular injury epidemiology, toxicology, and mechanisms.  J Am Coll Cardiol. 2008;  52(9) 719-726
    CrossrefPubMedSuche in Google Scholar
  • 32 O'Toole T E, Conklin D J, Bhatnagar A. Environmental risk factors for heart disease.  Rev Environ Health. 2008;  23(3) 167-202
    PubMedSuche in Google Scholar
  • 33 Suwa T, Hogg J C, Quinlan K B, Ohgami A, Vincent R, van Eeden S F. Particulate air pollution induces progression of atherosclerosis.  J Am Coll Cardiol. 2002;  39(6) 935-942
    CrossrefPubMedSuche in Google Scholar
  • 34 Chen L C, Nadziejko C. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. V. CAPs exacerbate aortic plaque development in hyperlipidemic mice.  Inhal Toxicol. 2005;  17(4-5) 217-224
    PubMedSuche in Google Scholar
  • 35 Sun Q, Wang A, Jin X et al.. Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model.  JAMA. 2005;  294(23) 3003-3010
    CrossrefPubMedSuche in Google Scholar
  • 36 Araujo J A, Barajas B, Kleinman M et al.. Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress.  Circ Res. 2008;  102 589-596
    CrossrefPubMedSuche in Google Scholar
  • 37 Künzli N, Jerrett M, Mack W J et al.. Ambient air pollution and atherosclerosis in Los Angeles.  Environ Health Perspect. 2005;  113(2) 201-206
    CrossrefPubMedSuche in Google Scholar
  • 38 Hoffmann B, Moebus S, Möhlenkamp S Heinz Nixdorf Recall Study Investigative Group et al. Residential exposure to traffic is associated with coronary atherosclerosis.  Circulation. 2007;  116(5) 489-496
    CrossrefPubMedSuche in Google Scholar
  • 39 Dominici F, McDermott A, Daniels D et al.. Mortality among residents of 90 cities.  In: Special Report: Revised Analyses of Time-Series Studies of Air Pollution and Health. Boston, MA; Health Effects Institute 2003: 9-24
    PubMedSuche in Google Scholar
  • 40 Analitis A, Katsouyanni K, Dimakopoulou K et al.. Short-term effects of ambient particles on cardiovascular and respiratory mortality.  Epidemiology. 2006;  17(2) 230-233
    CrossrefPubMedSuche in Google Scholar
  • 41 Biggeri A, Bellini O, Terracini B. Meta-analysis of the Italian studies on short-term effects of air pollution MISA 1996–2002.  Epidemiol Prev. 2004;  28(Suppl) 4-100
    PubMedSuche in Google Scholar
  • 42 Pope C A, Dockery D W. Health effects of fine particulate air pollution: lines that connect.  J Air Waste Manag Assoc. 2006;  56 709-742
    PubMedSuche in Google Scholar
  • 43 Dominici F, Peng R D, Bell M L et al.. Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases.  JAMA. 2006;  295(10) 1127-1134
    CrossrefPubMedSuche in Google Scholar
  • 44 Wellenius G A, Schwartz J, Mittleman M A. Particulate air pollution and hospital admissions for congestive heart failure in seven United States cities.  Am J Cardiol. 2006;  97(3) 404-408
    CrossrefPubMedSuche in Google Scholar
  • 45 Morris R D. Airborne particulates and hospital admissions for cardiovascular disease: a quantitative review of the evidence.  Environ Health Perspect. 2001;  109(Suppl 4) 495-500
    PubMedSuche in Google Scholar
  • 46 Pope III C A, Muhlestein J B, May H T, Renlund D G, Anderson J L, Horne B D. Ischemic heart disease events triggered by short-term exposure to fine particulate air pollution.  Circulation. 2006;  114(23) 2443-2448
    CrossrefPubMedSuche in Google Scholar
  • 47 Lanki T, Pekkanen J, Aalto P et al.. Associations of traffic related air pollutants with hospitalisation for first acute myocardial infarction: the HEAPSS study.  Occup Environ Med. 2006;  63(12) 844-851
    CrossrefPubMedSuche in Google Scholar
  • 48 von Klot S, Peters A, Aalto P Health Effects of Particles on Susceptible Subpopulations (HEAPSS) Study Group et al. Ambient air pollution is associated with increased risk of hospital cardiac readmissions of myocardial infarction survivors in five European cities.  Circulation. 2005;  112(20) 3073-3079
    CrossrefPubMedSuche in Google Scholar
  • 49 Peters A, von Klot S, Heier M Cooperative Health Research in the Region of Augsburg Study Group et al. Exposure to traffic and the onset of myocardial infarction.  N Engl J Med. 2004;  351(17) 1721-1730
    CrossrefPubMedSuche in Google Scholar
  • 50 Zanobetti A, Schwartz J. Air pollution and emergency admissions in Boston, MA.  J Epidemiol Community Health. 2006;  60(10) 890-895
    CrossrefPubMedSuche in Google Scholar
  • 51 Lewtas J. Air pollution combustion emissions: characterization of causative agents and mechanisms associated with cancer, reproductive, and cardiovascular effects.  Mutat Res. 2007;  636(1-3) 95-133
    PubMedSuche in Google Scholar
  • 52 Dockery D W, Pope III C A, Xu X et al.. An association between air pollution and mortality in six U.S. cities.  N Engl J Med. 1993;  329(24) 1753-1759
    CrossrefPubMedSuche in Google Scholar
  • 53 Laden F, Schwartz J, Speizer F E, Dockery D W. Reduction in fine particulate air pollution and mortality: Extended follow-up of the Harvard Six Cities study.  Am J Respir Crit Care Med. 2006;  173(6) 667-672
    CrossrefPubMedSuche in Google Scholar
  • 54 Pope III C A, Thun M J, Namboodiri M M et al.. Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults.  Am J Respir Crit Care Med. 1995;  151(3 Pt 1) 669-674
    CrossrefPubMedSuche in Google Scholar
  • 55 Pope III C A, Burnett R T, Thurston G D et al.. Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease.  Circulation. 2004;  109(1) 71-77
    PubMedSuche in Google Scholar
  • 56 Jerrett M, Burnett R T, Ma R et al.. Spatial analysis of air pollution and mortality in Los Angeles.  Epidemiology. 2005;  16(6) 727-736
    CrossrefPubMedSuche in Google Scholar
  • 57 Miller K A, Siscovick D S, Sheppard L et al.. Long-term exposure to air pollution and incidence of cardiovascular events in women.  N Engl J Med. 2007;  356(5) 447-458
    CrossrefPubMedSuche in Google Scholar
  • 58 Torén K, Bergdahl I A, Nilsson T, Järvholm B. Occupational exposure to particulate air pollution and mortality due to ischaemic heart disease and cerebrovascular disease.  Occup Environ Med. 2007;  64(8) 515-519
    CrossrefPubMedSuche in Google Scholar

Massimo FranchiniM.D. 

Immunohematology and Transfusion Center, Department of Pathology and Laboratory Medicine

University Hospital of Parma, Italy

eMail: mfranchini@ao.pr.it