Pharmacopsychiatry 2010; 43(4): 151-152
DOI: 10.1055/s-0029-1242821
Letter

© Georg Thieme Verlag KG Stuttgart · New York

Improvement of Mutism in a Catatonic Schizophrenia Case by Add-On Treatment with Amantadine

K. Muneoka1 , 2 , Y. Shirayama1 , 3 , K. Kon1 , M. Kawabe1 , M. Goto1 , S. Kimura1
  • 1Kimura Hospital, Chiba, Japan
  • 2Department of Anatomy I, Showa University School of Medicine, Tokyo, Japan
  • 3Department of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan
Further Information

Publication History

received 09.04.2009 revised 10.10.2009

accepted after revision 13.10.2009

Publication Date:
16 December 2009 (online)

It has been proposed that the pathophysiology of catatonia involves abnormalities in GABAergic, dopaminergic, and glutamatergic systems [3] [4]. We report that adding amantadine, an N-methyl-d-aspartate (NMDA) receptor antagonist [7]/indirect dopamine (DA) agonist, to combined risperidone (dopamine D2/5-HT2A receptor antagonist) and diazepam (a benzodiazepine GABAA receptor agonist) treatment can improve mutism in catatonic-type schizophrenia.

References

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Correspondence

K. MuneokaMD, PhD 

Kimura Hospital

6–19 Higashihon-cho

Chuo-ku Chiba-shi

260-0004 Chiba

Japan

Phone: +81/43/227 05 47

Fax: +81/43/225 07 51

Email: kmuneoka@med.showa-u.ac.jp