Abstract
This paper describes the antinociceptive action of I3,II8-binaringenin (GB-1a), a biflavonoid isolated from Clusia columnaris and present in several plants of the family Guttiferae, in a writhing test and a formalin test. It was found that it exhibits potent and dose-related antinociceptive action in both experimental models, with ID50 values of 22µmol/kg against the writhing test and 28µmol/kg against the second phase of the formalin test. It was more potent than some well-known analgesic drugs used as reference. Based on a hot- plate test its mechanism of action seems to be unrelated with the opioid receptors.
References
-
1 Luzzi R, Guimarães C L, Verdi L G, Simionatto E L, Delle Monache F, Yunes R A, Floriani A EO, Cechinel Filho V. Phytomedicine 1997 4: 141-144
-
2 Konoshima M, Ikeshiro Y, Nishinaga A, Matsuura T, Kubota T, Sakamoto S. Tetrahedron Lett 1969: 121-124
-
3 Konoshima M, Ikeshiro Y, Miyahara S, Yen K Y. Tetrahedron Lett 1970: 4203-4206
-
4 Duddeck H, Snatzke G, Yemul S S. Phytochemistry 1978 17: 1369-1373
-
5 Coterril P J, Scheinmann F, Stenhouse I. J Chem Soc, Perkin Trans 1978 I: 532-539
-
6 Ito C, Myamoto Y, Nakayama M, Kawai Y, Sundar Rao K, Furukawa H. Chem Pharm Bull 1997 45: 1403-1413
-
7 Lin Y M, Chen F C, Lee K H. Planta Med 1989 55: 166-168
-
8 Botta R, Mac-Quhae M, Delle Monache G, Delle Monache F, De Mello J F. J Nat Prod 1984 47: 1053
-
9 Lin Y M, Anderson H, Flavin M T, Mata-Greenwood E, Pengsuparp T, Pezzuto J M, Schinazi R F, Hughes S, Chen F C. J Nat Prod 1997 60: 884-888
-
10 Collier H DJ, Dinnin L C, Johnson C A, Schneider C. Brit J Pharmacol 1968 32: 295-310
-
11 Hunskaar S, Fasmar O B, Hole K. J Neurosci Methods 1985 14: 69-76
-
12 Willain Filho A, Breviglieri E, Cechinel Filho V, Santos A RS. J Pharm Pharmacol 1997 49: 823-827
-
13 Vaz Z R, Cechinel F ilho, Yunes R A, Calixto J B. J Pharmacol Exp Ther 1996 278: 304-312
-
14 Souza M M, Kern P, Floriani A EO, Cechinel Filho V. Phytother Res 1998 12: 279-281
-
15 Cechinel Filho V, Corrêa R, Vaz Z, Calixto J B, Nunes R J, Pinheiro T R, Andricopulo A D, Yunes R A. Il Farmaco 1998 53: 55-57
Valdir Cechinel Filho
Núcleo de Investigações
Químico-Farmacêuticas (NIQFAR)/CCS
Universidade do Vale do Itajaí (UNIVALI)
88302-202, Itajaí, SC
Brazil
eMail: cechinel@mbox1.univali.rct-sc.br
Fax: +55-47-3417601
