5-(4-Hydroxyphenethenyl)-4,7-dimethoxycoumarin, a New Constituent of Monotes engleri

Abstract

A new coumarin, 5-(4-hydroxyphenethenyl)-4,7-dimethoxycoumarin (1) was isolated from the combined ethyl acetate extracts of the root bark, root wood and stem bark of Monotes engleri, and found to be cytotoxic against two cell lines in a human tumor panel. Its structure was determined on the basis of spectroscopic methods.

References

• 1 Seo E -K, Silva G L, Chai H -B, Chagwedera T E, Farnsworth N R, Cordell G A, Pezzuto J M, Kinghorn A D. Phytochemistry 1997 45: 509-515
• 2 Silverstein R M, Bassler G C, Morrill T C. Spectroscopic Identification of Organic Compounds Fifth Edition. New York; John Wiley & Sons 1991: pp. 91-164
• 3 Vilegas W, Pozetti G L, Vilegas J HY. J. Nat. Prod 1993 56: 416-417
• 4 Abaul J, Philogéne É, Bourgeois P, Poupat C, Ahond A, Potier P. J Nat Prod 1994 57: 846-848
• 5 Debenedetti S L, Palacios P S, Nadinic E L, Coussio J D, de Kimpe N, Boeykens M, Feneau-Dupont J, Declercq J -P. J Nat Prod 1994 57: 1539-1542
• 6 Laakso J A, Narske E D, Gloer J B, Wicklow D T, Dowd P F. 1994 57: 128-133
• 7 Bax A. J Magn Res 1984 57: 314-318
• 8 Likhitwitayawuid K, Angerhofer C K, Cordell G A, Pezzuto J M, Ruangrungsi N. J Nat Prod 1993 56: 30-38