5-(4-Hydroxyphenethenyl)-4,7-dimethoxycoumarin, a New Constituent of Monotes engleri

Eun-Kyoung Seo; Hee-Byung Chai; Tangai E. Chagwedera; Norman R. Farnsworth; Geoffrey A. Cordell; John M. Pezzuto; A. Douglas Kinghorn*

doi:10.1055/s-0029-1243128

Planta Med 2000; 66(2): 182-184
DOI: 10.1055/s-0029-1243128

Letter

5-(4-Hydroxyphenethenyl)-4,7-dimethoxycoumarin, a New Constituent of Monotes engleri

Eun-Kyoung Seo¹ ^, ³ , Hee-Byung Chai¹ , Tangai E. Chagwedera² , Norman R. Farnsworth¹ , Geoffrey A. Cordell¹ , John M. Pezzuto¹ , A. Douglas Kinghorn¹ ^,*

¹Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, U.S.A.
²Department of Pharmacy, University of Zimbabwe, Harare, Zimbabwe
³Chemistry and Life Sciences Group, Research Triangle Institute, Research Triangle Park, North Carolina, U.S.A.

Abstract

A new coumarin, 5-(4-hydroxyphenethenyl)-4,7-dimethoxycoumarin (1) was isolated from the combined ethyl acetate extracts of the root bark, root wood and stem bark of Monotes engleri, and found to be cytotoxic against two cell lines in a human tumor panel. Its structure was determined on the basis of spectroscopic methods.

Full Text

References

1 Seo E -K, Silva G L, Chai H -B, Chagwedera T E, Farnsworth N R, Cordell G A, Pezzuto J M, Kinghorn A D. Phytochemistry 1997 45: 509-515
2 Silverstein R M, Bassler G C, Morrill T C. Spectroscopic Identification of Organic Compounds Fifth Edition. New York; John Wiley & Sons 1991: pp. 91-164
3 Vilegas W, Pozetti G L, Vilegas J HY. J. Nat. Prod 1993 56: 416-417
4 Abaul J, Philogéne É, Bourgeois P, Poupat C, Ahond A, Potier P. J Nat Prod 1994 57: 846-848
5 Debenedetti S L, Palacios P S, Nadinic E L, Coussio J D, de Kimpe N, Boeykens M, Feneau-Dupont J, Declercq J -P. J Nat Prod 1994 57: 1539-1542
6 Laakso J A, Narske E D, Gloer J B, Wicklow D T, Dowd P F. 1994 57: 128-133
7 Bax A. J Magn Res 1984 57: 314-318
8 Likhitwitayawuid K, Angerhofer C K, Cordell G A, Pezzuto J M, Ruangrungsi N. J Nat Prod 1993 56: 30-38

Prof. A. Douglas Kinghorn, Ph.D., D.Sc.

Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy

College of Pharmacy

University of Illinois at Chicago

833 South Wood Street (M/C 781)

Chicago, IL 60612

U.S.A.

Email: Kinghorn@uic.edu

Fax: +1-312-996-7107

Phone: +1-312-996-0914