Eremophilenolides from Ligularia fischeri

Abstract

The chemical investigation of Ligularia fischeri afforded three new eremophilenolides which were identified as 6β-methoxy-8β-hydroxy-eremophil-7(11)-en-12,8α-olide, ligufischerin, and 6-oxo-8β-hydroxy-eremophil-7(11)- en-12,8α-olide by 1D- and 2D-NMR spectra. In addition, six known eremophilenolides were also obtained.

References

• 1 Jiangsu College of New Medicine. A Dictionary of the Traditional Chinese Medicines. Beijing; People's Hygiene Publisher 1977: pp. 2305
• 2 Ishii H, Tozyo T, Minato H. J Chem Soc (C) 1966 17: 1545-1548
• 3 Ishii H, Tozyo T, Nakamura M, Nimato H. Tetrahedron 1970 62: 2911-2918
• 4 Moriyama Y, Sato T, Nagano H, Tanahashi Y, Takahashi T. Chem Lett 1972 7: 637-640
• 5 Sato T, Moriyama Y, Nagano H, Tanahashi Y, Takahashi T. Bull Chem Soc Jpn 1975 48: 112-114
• 6 Naya K, Kanazawa R, Sawada M. Bull Chem Soc Jpn 1975 48: 3220-3226
• 7 Zen-ichi H, Emiko Y, Tetsuaki T, Chuzo I. Chem Pharm Bull 1977 25: 2782-2784
• 8 Naya K, Matsumoto T, Makiyama M, Tsumura M. Heterocycles 1978 10: 177-184
• 9 Naya K, Nogi N, Makiyama Y, Takashina H, Imagava T. Bull Chem Soc Jpn 1977 50: 3002-3006
• 10 Moriyama Y, Takahashi T. Bull Chem Soc Jpn 1976 49: 3196-3199
• 11 Sugama K, Hayashi K, Mitsuhashi H. Phytochemistry 1985 24: 1531-1533
• 12 Moriyama Y, Takahashi T. Chem Pharm Bull 1976 24: 360-362
• 13 Novotny L, Herout V, Sorm F. Coll Czech Chem Commun 1964 29: 2189-2193
• 14 Jakupovic J, Pathak V P, Grenz M, Banerjee S, Wolfram C, Baruah R N, Bohlmann F. Phytochemistry 1987 26: 1049-1052
• 15 Yaoita Y, Kikuchi M. Chem Pharm Bull 1995 43: 1738-1743