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Klin Monbl Augenheilkd 2010; 227(5): 400-406
DOI: 10.1055/s-0029-1245375
Übersicht

© Georg Thieme Verlag KG Stuttgart · New York

Perforierende Keratoplastik bei Hornhautinfektionen durch Herpes-simplex-Virus und Varizella-zoster-Virus

Penetrating Keratoplasty in Corneal Infections with Herpes Simplex Virus and Varizella Zoster VirusF. Birnbaum1 , T. Reinhard1
  • 1Universitäts-Augenklinik Freiburg
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Publikationsverlauf

Eingegangen: 3.12.2009

Angenommen: 25.3.2010

Publikationsdatum:
20. Mai 2010 (online)

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Zusammenfassung

Perforierende Keratoplastiken bei Hornhautnarben durch rezidivierende Herpes-simplex-Virus-Entzündungen werden recht häufig durchgeführt. Deutlich seltener erfordern persistierende Infektionen durch das Varizella-zoster-Virus eine Hornhauttransplantation. Durch die meist vorliegenden Vaskularisationen und die Gefahr der rezidivierenden Virusreplikation gehören die Hornhauttransplantationen bei Herpes-simplex- und Varizella-zoster-Viren zur Gruppe der Risikokeratoplastiken. Durch Verbesserungen der medikamentösen Nachbehandlung mit Virustatika und systemischen Immunsuppressiva ließ sich die Prognose in den vergangenen Jahren deutlich optimieren. In dieser Übersichtsarbeit sollen die Besonderheiten bei der Indikationsstellung und bei der Nachbehandlung dargestellt werden.

Abstract

Penetrating keratoplasties due to herpetic corneal scars are more often performed compared to persisting Varizella zoster virus infections, which are quite seldom. Penetrating keratoplasties in herpetic corneas are risk keratoplasties due to the vascularisation and the risk of recurrent virus replication. The prognosis in these corneal transplantations has been improved in recent years due to better postoperative medical treatment with virustatics and systemic immunosuppression. Indications for and treatment following penetrating keratoplasty in herpetic eyes are the topics of this review.

Schlüsselwörter

Keratoplastik - Herpes-simplex-Virus - Varizella-zoster-Virus

Key words

penetrating keratoplasty - Herpes simplex virus - Varizella zoster virus

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PD Dr. Florian Birnbaum

Augenklinik, Universitätsklinik Freiburg

Killianstr. 5

79106 Freiburg

Telefon: ++ 49/7 61/2 70 40 01

Fax: ++ 49/7 61/2 70 40 63

eMail: florian.birnbaum@uniklinik-freiburg.de