Fortschr Neurol Psychiatr 2010; 78(8): 483-493
DOI: 10.1055/s-0029-1245470
Fort- und Weiterbildung

© Georg Thieme Verlag KG Stuttgart · New York

Riechstörungen in der Früh- und Differenzialdiagnose von Parkinson-Syndromen

Olfactory Dysfunction in Parkinsonian Syndromes. Its Role in Early and Differential DiagnosisB. Herting1
  • 1Klinik für Neurologie, Diakonie-Klinikum Schwäbisch Hall
Further Information

Publication History

Publication Date:
06 August 2010 (online)

Lernziele

Definition und Klassifikation von Parkinson-Syndromen Problematik der Differenzialdiagnose, insbesondere von idiopathischen und atypischen Parkinson-Syndromen Bedeutung von Riechtests in der Differenzialdiagnose von Parkinson-Syndromen Langzeitverlauf der Riechfunktion bei Patienten mit idiopathischem Parkinson-Syndrom (IPS), Multisystematrophie (MSA) und progressiver supranukleärer Blickparese (PSP) Riechstörungen als Frühsymptom, wahrscheinlich sogar Erstsymptom des IPS Chancen der frühen Diagnosestellung bei Risikopersonen noch in präklinischen Stadien eines IPS

Literatur

  • 1 Diener H C. et al .Leitlinien für Diagnostik und Therapie in der Neurologie. Stuttgart: Thieme Verlag KG; 2008. http://(www.dgn.org)
  • 2 Hughes A J, Daniel S E, Kilford L et al. Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinicopathological study of 100 cases.  J Neurol Neurosurg Psychiatry. 1992;  55 (3) 181-184
  • 3 Litvan I, Goetz C G, Jankovic J et al. What is the accuracy of the clinical diagnosis of multiple system atrophy? A clinicopathologic study.  Arch Neurol. 1997;  54 937-944
  • 4 Oertel W H, Schulz J B. Parkinson-Syndrome. In Brandt T, Dichgans J, Diener H C, (Hrsg) Therapie und Verlauf neurologischer Erkrankungen.. Stuttgart: Kohlhammer; 2003: 919-963
  • 5 Hummel T, Sekinger B, Wolf S R et al. „Sniffin’ sticks”: olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold.  Chem Senses. 1997;  22 39-52
  • 6 Wenning G K, Shephard B, Hawkes C et al. Olfactory function in atypical parkinsonian syndromes.  Acta Neurol Scand. 1995;  91 274-250
  • 7 Mueller A, Reichmann H, Livermore A et al. Olfactory function in idiopathic Parkinson’s disease (IPD): results from cross-sectional studies in IPD patients and long-term follow-up of de-novo IPD patients.  J Neural Transm. 2002a;  109 805-811
  • 8 Mueller A, Muengersdorf M, Reichmann H et al. Olfactory function in parkinsonian syndromes.  J Clin Neurosc. 2002b;  9 521-524
  • 9 Ondo W G, Lai D. Olfaction testing in patients with tremor dominant Parkinson’s disease. Is this a distinct condition?.  Mov Disord. 2005;  20 471-475
  • 10 Katzenschlager R, Lees A J. Olfaction and Parkinson’s syndromes: its role in differential diagnosis.  Curr Opin Neurol. 2004;  17 417-423
  • 11 Katzenschlager R, Zijlmans J, Evans A et al. Olfactory function distinguishes vascular parkinsonism from Parkinson’s disease.  J Neurol Neurosurg Psychiatry. 2004;  75 1749-1752
  • 12 Khan N L, Katzenschlager R, Watt H et al. Olfaction differentiates parkin disease from early-onset parkinsonism and Parkinson disease.  Neurology. 2004;  62 1224-1226
  • 13 Hawkes C H. Olfaction in neurodegenerative disorder.  Mov Disord. 2003;  18 (4) 364-372
  • 14 Doty R L, Singh A, Tertrud L et al. Lack of major olfactory dysfunction in MPTP-induced parkinsonism.  Ann Neurol. 1992;  32 97-100
  • 15 Herting B, Schulze S, Reichmann H et al. A longitudinal study of olfactory function in patients with idiopathic Parkinson’s disease.  J Neurol. 2008;  255 (3) 367-370
  • 16 Doty R L, Deems D A, Steller S. Olfactory dysfunction in parkinsonism: A general deficit unrelated to neurologic signs, disease stage, or disease duration.  Neurology. 1988;  38 1237-1244
  • 17 Hawkes C H, Shephard B C, Daniel S E. Is Parkinson’s disease a primary olfactory disorder?.  Qjm. 1999;  92 473-480
  • 18 Ponsen M M, Stoffers D, Booji J et al. Idiopathic hyposmia as a preclinical sign of Parkinson’s disease.  Ann Neurol. 2004;  56 173-181
  • 19 Haehner A, Hummel T, Hummel C et al. Olfactory loss may be a first sign of idiopathic Parkinson’s disease.  Mov Disord. 2007;  22 (6) 839-842
  • 20 Braak H, Tredici K D, Rub U et al. Staging of brain pathology related to sporadic Parkinson’s disease.  Neurobiol Aging. 2003;  24 197-211
  • 21 Braak H, Vos de R, Bohl J et al. Gastric alpha-synuclein immunreactive inclusions in Meissner’s and Auerbach’s plexuses in cases staged for Parkinson’s disease-related brain pathology.  Neuroscience Letters. 2006;  396 67-72
  • 22 Huisman E, Uylings H B, Hoogland P V. A 100 % increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson’s disease.  Mov Disord. 2004;  19 (6) 687-692
  • 23 Sommer U, Hummel T, Cormann K et al. Detection of presymptomatic Parkinson’s disease: Combining smell test, transcranial sonography, and SPECT.  Mov Disord. 2004;  19 (10) 1196-1202
  • 24 Berendse H W, Booij J, Francot C M J et al. Subclinical dopaminergic dysfunction in asymptomatic Parkinson disease patients’ relatives with decreased sense of smell.  Ann Neurol. 2001;  50 34-41
  • 25 Stiasny-Kolster K, Doerr Y, Moller J C et al. Combination of ‘idiopathic’ REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT.  Brain. 2005;  128 (Pt 1) 126-137
  • 26 Postuma R B, Lang A E, Massicotte-Marquez J et al. Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder.  Neurology. 2006;  66 845-851
  • 27 Berg D. Marker for a preclinical diagnosis of Parkinson’s disease as a basis for neuroprotection.  J Neural Transm. 2006;  71 (Suppl) 123-132
  • 28 Stern M B. The preclinical detection of Parkinson’s disease: ready for prime time?.  Ann Neurol. 2004;  56 169-171
  • 29 Berendse H W, Ponsen M M. Detection of preclinical Parkinson’s disease along the olfactory tract.  J Neural Transm. 2006;  70 (Suppl) 321-325

PD Dr. med. Birgit Herting

Klinik für Neurologie Diakonie-Klinikum gGmbH

Diakoniestraße 10

74523 Schwäbisch Hall

Email: birgit.herting@dasdiak.de