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Klinische Neurophysiologie 2010; 41(2): 106-115
DOI: 10.1055/s-0030-1248408
DOI: 10.1055/s-0030-1248408
Fort- und Weiterbildung
© Georg Thieme Verlag KG Stuttgart · New York
Frühdiagnose der möglichen Alzheimer-Erkrankung anhand neuer Forschungskriterien
Early Diagnosis of Probable Alzheimer's Disease (AD) Based on New Research CriteriaFurther Information
Publication History
Publication Date:
24 June 2010 (online)

Lernziele
Kenntnisse über
Schwierigkeiten und Notwendigkeit der frühzeitigen Diagnose einer Alzheimer-Erkrankung Forschungskriterien zur Diagnose im Prodromalstadium der Alzheimer-Erkrankung Möglichkeiten und Grenzen der Forschungskriterien
Literatur
- 1 Dubois B. et al . Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol. 2007; 6 734-746
- 2 McKhann G. et al . Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984; 34 939-944
- 3 Gilman S. et al . Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology. 2005; 64 1553-1562
- 4 Peterse R C. Mild cognitive impairment as a diagnostic entity. J Intern Med. 2004; 256 183-194
- 5 Petersen R C. et al . Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999; 56 303-308
- 6 Feldman H H. et al . Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study. Lancet Neurol. 2007; 6 501-512
- 7 Petersen R C. et al . Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med. 2005; 352 2379-2388
- 8 Winblad B. et al . Safety and efficacy of galantamine in subjects with mild cognitive impairment. Neurology. 2008; 70 2024-2035
- 9 Thal L J. et al . A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment. Neuropsychopharmacology. 2005; 30 1204-1215
- 10 Förstl H. et al . [MCI-plus: mild cognitive impairment with rapid progression. Part II: Biomarkers and research methods]. Dtsch Med Wochenschr. 2009; 134 88-91
- 11 Jicha G A. et al . Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia. Arch Neurol. 2006; 63 674-681
- 12 Varma A R. et al . Evaluation of the NINCDS-ADRDA criteria in the differentiation of Alzheimer's disease and frontotemporal dementia. J Neurol Neurosurg Psychiatry. 1999; 66 184-188
- 13 Buschke H. et al . Diagnosis of early dementia by the Double Memory Test: encoding specificity improves diagnostic sensitivity and specificity. Neurology. 1997; 48 989-997
- 14 Jack Jr C R. et al . Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia. Neurology. 2002; 58 750-757
- 15 Deweer B. et al . Memory disorders in probable Alzheimer's disease: the role of hippocampal atrophy as shown with MRI. J Neurol Neurosurg Psychiatry. 1995; 58 590-597
- 16 de Leon M J. et al . Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiol Aging. 2006; 27 394-401
- 17 Scheltens P. et al . Structural magnetic resonance imaging in the practical assessment of dementia: beyond exclusion. Lancet Neurol. 2002; 1 13-21
- 18 Bottino C M. et al . Volumetric MRI measurements can differentiate Alzheimer's disease, mild cognitive impairment, and normal aging. Int Psychogeriatr. 2002; 14 59-72
- 19 Visser P J. et al . Medial temporal lobe atrophy and memory dysfunction as predictors for dementia in subjects with mild cognitive impairment. J Neurol. 1999; 246 477-485
- 20 Visser P J. et al . Medial temporal lobe atrophy predicts Alzheimer's disease in patients with minor cognitive impairment. J Neurol Neurosurg Psychiatry. 2002; 72 491-497
- 21 Dickerson B C. et al . MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer’s disease. Neurobiol Aging. 2001; 22 747-754
- 22 Blennow K, Hampel H. CSF markers for incipient Alzheimer's disease. Lancet Neurol. 2003; 2 605-613
- 23 Hansson O. et al . Association between CSF biomarkers and incipient Alzheimer’s disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol. 2006; 5 228-234
- 24 Peskind E R. et al . Safety and acceptability of the research lumbar puncture. Alzheimer Dis Assoc Disord. 2005; 19 220-225
- 25 Patwardhan M B. et al . Alzheimer disease: operating characteristics of PET--a meta-analysis. Radiology. 2004; 231 73-80
- 26 Minoshima S. et al . Alzheimer's disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation. Ann Neurol. 2001; 50 358-365
- 27 Koeppe R A. et al . 11C-DTBZ and 18F-FDG PET measures in differentiating dementias. J Nucl Med. 2005; 46 936-944
- 28 Anchisi D. et al . Heterogeneity of brain glucose metabolism in mild cognitive impairment and clinical progression to Alzheimer disease. Arch Neurol. 2005; 62 1728-1733
- 29 Klunk W E. et al . Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B. Ann Neurol. 2004; 55 306-319
- 30 Fagan A M. et al . Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans. Ann Neurol. 2006; 59 512-519
- 31 Shoghi-Jadid K. et al . Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease. Am J Geriatr Psychiatry. 2002; 10 24-35
- 32 Mintun M A. et al . [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology. 2006; 67 446-452
- 33 Dougall N J, Bruggink S, Ebmeier K P. Systematic review of the diagnostic accuracy of 99mTc-HMPAO-SPECT in dementia. Am J Geriatr Psychiatry. 2004; 12 554-570
- 34 O’Brien J T. et al . Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies. Arch Neurol. 2004; 61 919-925
- 35 Borroni B. et al . Combined 99mTc-ECD SPECT and neuropsychological studies in MCI for the assessment of conversion to AD. Neurobiol Aging. 2006; 27 24-31
- 36 Huang C. et al . Imaging markers of mild cognitive impairment: multivariate analysis of CBF SPECT. Neurobiol Aging. 2007; 28 1062-1069
- 37 Kung M P. et al . Characterization of IMPY as a potential imaging agent for beta-amyloid plaques in double transgenic PSAPP mice. Eur J Nucl Med Mol Imaging. 2004; 31 1136-1145
- 38 Galton C J. et al . Atypical and typical presentations of Alzheimer's disease: a clinical, neuropsychological, neuroimaging and pathological study of 13 cases. Brain. 2000; 123 484-498
- 39 Luck T. et al . Mild cognitive impairment in general practice: age-specific prevalence and correlate results from the German study on ageing, cognition and dementia in primary care patients (AgeCoDe). Dement Geriatr Cogn Disord. 2007; 24 307-316
PD Dr. med. Notger Müller
Universitätsklinik für Neurologie und Deutsches Zentrum für Neurodegenerative Erkrankungen
Leipziger Straße 44
39120 Magdeburg
Email: notger.mueller@med.ovgu.de