Planta Med 2010; 76(14): 1600-1604
DOI: 10.1055/s-0030-1249777
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Antiplasmodial, Antitrypanosomal, and Cytotoxic Activities of Prenylated Flavonoids Isolated from the Stem Bark of Artocarpus styracifolius

Mélanie Bourjot1 , Cécile Apel1 , Marie-Thérèse Martin1 , Philippe Grellier2 , Van Hung Nguyen3 , Françoise Guéritte1 , Marc Litaudon1
  • 1Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France
  • 2Museum National d'Histoire Naturelle, Paris, France
  • 3Institute of Chemistry, VAST, Hanoi, Vietnam
Further Information

Publication History

received Dec. 18, 2009 revised March 4, 2010

accepted March 7, 2010

Publication Date:
08 April 2010 (online)

Abstract

In continuation of our efforts to find new antimalarial drugs, a systematic in vitro evaluation using a chloroquine resistant strain of Plasmodium falciparum (FcB1) was undertaken on extracts prepared from various parts of Vietnamese plants. The ethyl acetate extract obtained from the stem bark of Artocarpus styracifolius (Moraceae) exhibited strong antiplasmodial activity (87 % at 10 µg/mL) whereas weak cytotoxicity was observed in a human fibroblast cell line (MRC-5). Phytochemical investigation of this extract led to isolation of two new prenylated flavonoids, styracifolins A and B (1 and 2), as well as the known artoheterophyllin A (3) and B (4), artonins A (5), B (6), and F (7), and heterophyllin (8). Structures of 1 and 2 were elucidated by spectroscopic methods and through comparison with data reported in the literature. Compounds 18 exhibited antiplasmodial activities with IC50 values ranging from 1.1 µM to 13.7 µM, and compounds 1, 2, 6, and 8 showed significant antitrypanosomal activities.

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Dr. Marc Litaudon

Institut de Chimie des Substances Naturelles

1 avenue de la Terrasse

91198 Gif-sur-Yvette

Cedex

France

Phone: + 33 1 69 82 30 85

Fax: + 33 1 69 07 72 47

Email: marc.litaudon@icsn.cnrs-gif.fr