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DOI: 10.1055/s-0030-1249810
© Georg Thieme Verlag KG Stuttgart · New York
The Intestinal Permeability of Neolignans from the Seeds of Myristica fragrans in the Caco-2 Cell Monolayer Model
Publikationsverlauf
received Sept. 21, 2009
revised March 14, 2010
accepted March 16, 2010
Publikationsdatum:
13. April 2010 (online)
![](https://www.thieme-connect.de/media/plantamedica/201014/lookinside/thumbnails/10.1055-s-0030-1249810-1.jpg)
Abstract
The intestinal permeability and transport of 10 neolignans isolated from Myristica fragrans were studied by using the Caco-2 cell monolayer model. The 10 neolignans were measured by HPLC. Transport parameters and permeability coefficients were then calculated and compared with those of the model compounds, propranolol and atenolol. Among the 10 neolignans, the 8-O-4′-type neolignans demonstrated high permeability while the benzofuran-type neolignans were of poor to moderate permeability. Among them, eight neolignans were transported mainly via passive diffusion. These findings indicate that the 8-O-4′-type neolignans are well-absorbed compounds and can be used as oral leading compounds in drug discovery.
Key words
Myristicaceae - Myristica fragrans - neolignans - intestinal permeability - Caco‐2 cell monolayer
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Prof. Dr. Xiu-Wei Yang
State Key Laboratory of Natural and Biomimetic Drugs
School of Pharmaceutical Sciences
Peking University
38 Xueyuan Road
Haidian District
100191 Beijing
China
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Fax: + 86 10 82 80 27 24
eMail: xwyang@bjmu.edu.cn