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DOI: 10.1055/s-0030-1249820
© Georg Thieme Verlag KG Stuttgart · New York
Vasorelaxant Activity of Essential Oils from Croton zambesicus and Some of Their Constituents
Publication History
received August 28, 2009
revised March 12, 2010
accepted March 19, 2010
Publication Date:
26 April 2010 (online)
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Abstract
In this study, we determined the vasorelaxant activity of essential oils of different samples of Croton zambesicus collected in the same area in Benin at different periods and analysed their compositions by GC‐FID and GC‐MS. 68 compounds were identified among which 20 have not been described previously in this plant's essential oils. We observed quantitative differences among essential oils but all possess significant vasorelaxant activity on intact rat aortae contracted by KCl (IC50 5.6–11.8 µg/mL). This activity may, at least in part, be explained by the presence of vasorelaxant diterpenes such as ent-18-hydroxy-trachyloban-3-one, isopimara-7,15-dien-3β‐ol, and ent-18-hydroxy-isopimar-7,15-dien-3β‐ol, previously isolated from the dichloromethane extract of the leaves, but also to linalool (IC50 43.4 µg/mL) and particularly to caryophyllene oxide (IC50 2.5 µg/mL).
Key words
vasorelaxant activity - essential oil - Croton zambesicus - Euphorbiaceae - terpenes
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Prof. Joelle Quetin-Leclercq
CHAM Unit
Louvain Drug Research Institute
Université catholique de Louvain
Avenue E. Mounier 72–30
1200 Brussels
Belgium
Phone: + 32 27 64 72 30
Fax: + 32 27 64 72 53
Email: joelle.leclercq@uclouvain.be
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