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DOI: 10.1055/s-0030-1249861
© Georg Thieme Verlag KG Stuttgart · New York
Evaluation of Cytotoxic Activity of Schisandra chinensis Lignans
Publikationsverlauf
received January 8, 2010
revised March 18, 2010
accepted March 31, 2010
Publikationsdatum:
10. Mai 2010 (online)
![](https://www.thieme-connect.de/media/plantamedica/201015/lookinside/thumbnails/10.1055-s-0030-1249861-1.jpg)
Abstract
Using exhaustive chromatographic separation we have isolated (−)-tigloyl-deangeloyl-gomisin F as a novel dibenzocyclooctadiene lignan from Schisandra chinensis. With the help of HPLC, we further isolated (+)-schisandrin, (+)-deoxyschisandrin, (+)-γ-schisandrin, (−)-gomisin J, (+)-gomisin A, (−)-gomisin N, (−)-tigloyl-gomisin P, (−)-wuweizisu C, (−)-gomisin D, rubrisandrin A, (−)-gomisin G, (+)-gomisin K3 and (−)-schisantherin C. A full NMR description of (−)-schisantherin C was carried out with the aim to confirm previous reports of its structure. Compounds isolated were identified on the basis of UV, IR, 1H- and 13C‐NMR and MS. The cytotoxicity of lignans was tested for the BY-2 cell line alone and as a synergistic effect with the cytotoxic agent camptothecin. Lignans showed various toxicity and synergistic and antagonistic effects on camptothecin-induced cytotoxicity. Cytotoxicity against colon cancer cell line LoVo was also tested.
Key words
Schisandra chinensis - Schisandraceae - dibenzocyclooctadiene lignans - cytotoxicity
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Karel Šmejkal
Department of Natural Drugs
Faculty of Pharmacy
University of Veterinary and Pharmaceutical Sciences Brno
Palackého 1–3
61242 Brno
Czech Republic
Telefon: + 42 05 41 56 28 39
eMail: karel.mejkal@post.cz
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