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DOI: 10.1055/s-0030-1249936
© Georg Thieme Verlag KG Stuttgart · New York
Cytotoxic Chaetoglobosins from the Endophyte Chaetomium globosum
Publikationsverlauf
received February 4, 2010
revised March 28, 2010
accepted April 16, 2010
Publikationsdatum:
19. Mai 2010 (online)
![](https://www.thieme-connect.de/media/plantamedica/201016/lookinside/thumbnails/10.1055-s-0030-1249936-1.jpg)
Abstract
Two new alkaloids chaetoglobosins V (1) and W (2), together with the six known congeners 3–8, were isolated through bioassay-guided fractionations from the EtOAc extract of a solid culture of Chaetomium globosum IFB-E041. The structures were elucidated by spectroscopic methods including mainly 1D and 2D NMR techniques. Chaetoglobosin W (2) was unique in its possession of an oxolane ring formed via an oxygen bridge between C-3 and C-6. The isolated fungal metabolites exhibited moderate cytotoxic activities against four human cancer cell lines (KB, K562, MCF-7, and HepG2) with their IC50 values in a range of 18–30 µg/mL.
Key words
Chaetomium globosum - Chaetomiaceae - chaetoglobosin - cytotoxicity - structure elucidation
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