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DOI: 10.1055/s-0030-1249960
© Georg Thieme Verlag KG Stuttgart · New York
Antihyperlipidemic Effect of Protodioscin, an Active Ingredient Isolated from the Rhizomes of Dioscorea nipponica
Publikationsverlauf
received Dec. 17, 2009
revised March 26, 2010
accepted April 16, 2010
Publikationsdatum:
27. Mai 2010 (online)
![](https://www.thieme-connect.de/media/plantamedica/201015/lookinside/thumbnails/10.1055-s-0030-1249960-1.jpg)
Abstract
Developing drugs against metabolic-related disorders, including obesity and hyperlipidemia, is of importance for human health. Here, a bioactive phytochemical, protodioscin, isolated from the rhizomes of Dioscorea nipponica (Rhizoma Dioscoreae Nipponicae), was identified for its anti-hyperlipidemic effect. In hyperlipidemic rats, the post-administration of protodioscin significantly reduced the time of blood coagulation. In addition, the blood levels of triglyceride, cholesterol, low-density and high-density lipoproteins were also changed accordingly. Taken together, this was the first report of an antihyperlipidemic effect of protodioscin. Its great availability in various vegetables and medicinal plants will be useful in developing health food supplement(s) and/or drug(s) against hyperlipidemia.
Key words
Dioscorea nipponica Makino - Disocorea L. - Dioscoreaeceae - protodoscin - hyperlipidemic
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Prof. Dr. Karl W. K. Tsim
Department of Biology
The Hong Kong University of Science and Technology
Clear Water Bay Road, Kowloon Hong Kong
NIL Hong Kong
China
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