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DOI: 10.1055/s-0030-1250006
Historic Perspectives on Annonaceous Acetogenins from the Chemical Bench to Preclinical Trials
Publication History
received Nov. 30, 2009
revised April 26, 2010
accepted April 28, 2010
Publication Date:
24 June 2010 (online)
![](https://www.thieme-connect.de/media/plantamedica/201013/lookinside/thumbnails/10.1055-s-0030-1250006-1.jpg)
Abstract
Studies on the Annonaceous acetogenins began after the first cytotoxic acetogenin, uvaricin, was isolated in 1982. This attractive finding made many medicinal and natural product chemists direct their efforts on the isolation and identification of these classes of compounds. As more Annonaceous acetogenins were isolated, more information about them was uncovered. From their structural identification to the total synthesis of natural product analogues and from cell-based screening and molecular-based targeting to animal testing, the mechanisms of action of the Annonaceous acetogenins became clearer. The purpose of this review is to give an account of recent studies on this class of compounds and their analogues, which will aid us not only in clarifying how the Annonaceous acetogenins act but also in establishing principles for the further development of this class of compounds.
Key words
Annonaceae - acetogenins - mitochondria complex I inhibitor - pesticidal activity - anticancer activity - apoptosis - acetogenin mimics
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Dr. Yang-Chang Wu
Graduate Institute of Natural Products
Kaohsiung Medical University
100 Shih-Chuan 1st Road
703 Kaohsiung
Taiwan
Republic of China
Phone: + 88 6 73 12 11 01ext. 21 97
Fax: + 88 6 73 11 47 73
Email: yachwu@kmu.edu.tw