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Planta Med 2010; 76(16): 1847-1851
DOI: 10.1055/s-0030-1250061
Pharmacology
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

African Descents Are More Sensitive Than European Descents to the Antitumor Compounds α-Hederin and Kalopanaxsaponin I

Geva Feller1 , Aleksandra Kugel1 , Dana Moonshine1 , Vered Chalifa-Caspi1 , Martin Scholz2 , Dirk Prüfer2 , 3 , Tatiana Rabinski4 , Kai J. Müller3 , Rivka Ofir4
  • 1Ben Gurion University of the Negev, Bioinformatic Core Facility, National Institute of Biotechnology in the Negev, Beer Sheva, Israel
  • 2Institute for Biochemistry and Biotechnology of Plants (IBBP), Westphalian Wilhelms-University Münster, Münster, Germany
  • 3Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Aachen, Germany
  • 4Dead Sea & Arava Science Center, 86910, Israel, and Department of Immunology and Microbiology, Health Sciences, Ben Gurion University of the Negev, Beer Sheva, 84105, Israel
Further Information

Publication History

received March 21, 2010 revised May 17, 2010

accepted May 28, 2010

Publication Date:
24 June 2010 (online)

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Erratum for: African Descents Are More Sensitive Than European Descents to the Antitumor Compounds α-Hederin and Kalopanaxsaponin IPlanta Med 2010; 76(16): E8-E8
DOI: 10.1055/s-0030-1250325

Abstract

α-Hederin, a natural triterpene saponin and its derivative kalopanaxsaponin I (ksI) exhibit cytotoxicity against various cancer cell lines and in vivo tumors. We studied the genetic variants contributing to the activity of these two anticancer compounds. Cell lines derived from 30 trios of European descent (Centre d'Etude du Polymorphisme Human, CEPH; CEU) and 30 trios of African descent (Yoruban, YRI) were used. Cytotoxicity was determined as inhibition of cell growth at increasing concentrations of α-hederin or ksI for 24 h. In comparison to the European, the Yoruban populations revealed a higher sensitivity to α-hederin and to ksI that can be attributed to several unique SNPs. These SNPs are located near 111 and 130 genes in the European and the Yoruban populations, respectively, raising the possibility that some of these genes contribute to the differential sensitivity to these compounds.

Key words

α‐hederin - kalopanaxsaponin I - Nigella sativa - Ranunculaceae - HapMap - lymphoblastoid cell lines - whole genome association

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Dr. Rivka Ofir

Dead Sea & Arava Science Center, 86910 Israel and
Department of Immunology and Microbiology, Health Sciences
Ben Gurion University of the Negev

P. O. Box 653

84105 Beer Sheva

Israel

Phone: + 97 25 23 44 89 82

Fax: + 9 72 86 58 20 68

Email: rivir@bgu.ac.il