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DOI: 10.1055/s-0030-1250061
© Georg Thieme Verlag KG Stuttgart · New York
African Descents Are More Sensitive Than European Descents to the Antitumor Compounds α-Hederin and Kalopanaxsaponin I
Publikationsverlauf
received March 21, 2010
revised May 17, 2010
accepted May 28, 2010
Publikationsdatum:
24. Juni 2010 (online)
![](https://www.thieme-connect.de/media/plantamedica/201016/lookinside/thumbnails/10.1055-s-0030-1250061-1.jpg)
Abstract
α-Hederin, a natural triterpene saponin and its derivative kalopanaxsaponin I (ksI) exhibit cytotoxicity against various cancer cell lines and in vivo tumors. We studied the genetic variants contributing to the activity of these two anticancer compounds. Cell lines derived from 30 trios of European descent (Centre d'Etude du Polymorphisme Human, CEPH; CEU) and 30 trios of African descent (Yoruban, YRI) were used. Cytotoxicity was determined as inhibition of cell growth at increasing concentrations of α-hederin or ksI for 24 h. In comparison to the European, the Yoruban populations revealed a higher sensitivity to α-hederin and to ksI that can be attributed to several unique SNPs. These SNPs are located near 111 and 130 genes in the European and the Yoruban populations, respectively, raising the possibility that some of these genes contribute to the differential sensitivity to these compounds.
Key words
α‐hederin - kalopanaxsaponin I - Nigella sativa - Ranunculaceae - HapMap - lymphoblastoid cell lines - whole genome association
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Dr. Rivka Ofir
Dead Sea & Arava Science Center, 86910 Israel and
Department of Immunology and Microbiology, Health Sciences
Ben Gurion University of the Negev
P. O. Box 653
84105 Beer Sheva
Israel
Telefon: + 97 25 23 44 89 82
Fax: + 9 72 86 58 20 68
eMail: rivir@bgu.ac.il