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DOI: 10.1055/s-0030-1250113
© Georg Thieme Verlag KG Stuttgart · New York
Novel Flavonoids from the Leaves of Actinidia valvata Dunn: Structural Elucidation and Antioxidant Activity
Publication History
received January 20, 2010
revised June 2, 2010
accepted June 10, 2010
Publication Date:
21 July 2010 (online)
Abstract
Two novel flavonoids, kaempferol 3-O-α-L-rhamnopyranosyl (1–3) (2,4-di-O-acetyl-α-L-rhamnopyranosyl) (1–6) β-D-galactopyranoside (1) and kaempferol 3-O-α-L-rhamnopyranosyl (1–3) (4-O-acetyl-α-L-rhamnopyranosyl) (1–6) β-D-galactopyranoside (2), along with three known ones, kaempferol-3-O-β-D-galactopyranoside (3), kaempferol (4), and 7-hydroxychromone (5), have been isolated from the leaves of Actinidia valvata Dunn, and their structures were elucidated based on spectroscopic methods. Compounds 1 – 3 exhibited dose-dependent activity in scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals, superoxide anion radicals, and hydroxyl radicals, and inhibited lipid peroxidation of mouse liver homogenate in vitro.
Key words
Actinidia valvata - Actinidiaceae - flavonoid glycosides
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References
- 1 Delectis Florae Reipublicae Popularis Sinicae Agendae Academiae Sinicae Edita .Flora of China (Volume 49, Tomus 2). Beijing; Science Press 1984: 205
- 2 Webby R F, Wilson R D, Ferguson A R. Leaf flavonoids of Actinidia. Biochem Syst Ecol. 1994; 22 277-286
- 3 Xin H L, Wu Y C, Xu Y F, Zhang Y N, Ling C Q. A comparison between the root and stalk of Actinidia valvata. Acad J Sec Mil Med Univ. 2008; 29 298-302
- 4 Zhang Y N, Liu L, Ling C Q. Inhibition effect of active fraction from Actinidia valvata on growth of transplanted mouse tumor cells and preliminary study of its mechanism. Chin J Chin Mater Med. 2006; 31 918-920
- 5 Lv Y, Yang X B, Zhao Y, Ruan Y, Yang Y, Wang Z Z. Separation and quantification of component monosaccharides of the tea polysaccharides from Gynostemma pentaphyllum by HPLC with indirect UV detection. Food Chem. 2009; 112 742-746
- 6 Lakenbrink C, Lam T M, Engelhardt U H, Wray V. New flavonol triglycosides from tea (Camellia sinensis). Nat Prod Lett. 2000; 14 233-238
- 7 Kashiwada Y, Nonaka G I, Nishioka I. Studies on rhubarb (Rhei rhizoma). VI. Isolation and characterization of stilbenes. Chem Pharm Bull. 1984; 32 3501-3517
- 8 Ouyang A M, Zhou J N. Flavonoid glycosides from the leaves of Davidio involucrate. Guangxi Flora. 2003; 23 568-570
- 9 Nenandis N, Wang L F, Tsimidou M Z, Zhang H Y. Radical scavenging potential of phenolic compounds encountered in O. europaea products as indicated by calculation of bond dissociation enthalpy and ionization potential values. J Agric Food Chem. 2005; 26 295-299
- 10 Burda S, Oleszek W. Antioxidant and antiradical activities of flavonoids. J Agric Food Chem. 2001; 49 2774-2779
- 11 Natella F, Nardini M, Di Felice M, Saccini C. Benzoic and cinnamic acid derivatives as antioxidants: structure–activity relation. J Agric Food Chem. 1999; 47 1453-1459
- 12 Cho J, Lee H K. Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells. Eur J Pharmacol. 2004; 485 105-110
- 13 Valentova K, Cvak L, Muck A, Ulrichova J, Simanek V. Antioxidant activity of extracts from the leaves of Smallanthus sonchifolius. Eur J Nutr. 2003; 42 61-66
- 14 Smirnoff N, Cumbes Q J. Hydroxyl radical scavenging activity of compatible solutes. Phytochemistry. 1989; 28 1057-1060
- 15 Sun X W, Sun Q, Jin M, Piao C M, Li L H. Effect of Sorbaria sorbifolia extract on anti-oxidative activities in rats with precancerosis induced by diethylnitrosamine. Chin J Integr Med. 2003; 1 47-50
Chang-Quan Ling
Department of Traditional Chinese Medicine
Changhai Hospital
The Second Military Medical University
No. 800, Xiangyin Road
200433 Shanghai
P. R. China
Phone: + 86 21 81 87 15 51
Fax: + 86 21 81 87 15 59
Email: lingchangquan@hotmail.com
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