RSS-Feed abonnieren
DOI: 10.1055/s-0030-1250147
© Georg Thieme Verlag KG Stuttgart · New York
A Rare Case of Left Main Coronary Stenosis and Neutropenia Treated with G-CSF Prior to CABG
Publikationsverlauf
received February 13, 2010
Publikationsdatum:
26. November 2010 (online)
Abstract
A 70-year-old male known with myelodysplastic syndrome (MDS) was admitted with effort angina and fever, which developed into unstable angina. On coronary angiography a critical stenosis of the left main coronary artery and 75 % stenosis of the right coronary artery were found. On complete blood count the number of leukocytes was 1600/µl. We administered granulocyte colony-stimulating factor (G-CSF) twice daily to increase the number of leucocytes. After two days the number of leukocytes had increased to 8700/µl. The patient was admitted to the operating room and off-pump coronary artery bypass grafting was performed successfully.
Key words
Neutropenia - granulocyte colony-stimulating factor - myelodysplastic syndrome - coronary artery bypass grafting
References
- 1 Pollmacher T, Korth C, Schreiber W et al. Effects of repeated administration of granulocyte colony-stimulating factor (G-CSF) on neutrophil counts, plasma cytokine and cytokine receptor levels. Cytokine. 1996; 8 799-803
- 2 Malcovati L, Nimer S D. Myelodysplastic syndromes: diagnosis and staging. Cancer Control. 2008; 15 (Suppl.) 4
- 3 Rozman C, Montserrat E. Chronic lymphocytic leukemia. N Engl J Med. ; 333 (16)
- 4 Shapiro J, Fetherston G, Richardson G. Prevention of infection in patient with chronic idiopathic neutropenia undergoing coronary bypass surgery with preoperative G-CSF. ANZ J Surg. 1996; 66 841-842
- 5 Freedman M H, Bonilla M A, Fier C et al. Myelodysplasia syndrome and acute myeloid leukemia in patients with congenital neutropenia receiving G-CSF therapy. Blood. 2000; 92 (2) 429-436
- 6 Tanaka K, Kanemitsu S, Tanaka J, Suzuki H, Kinoshita T. Successful replacement of aortic valve using a stentless porcine valve in a patient with myelodysplastic syndrome. Ann Thorac Cardiovasc Surg. 2008; 14 2
- 7 Miyagi Y, Yamauchi S, Suzuki S, Kitagawa A, Masaki Y, Gomibuchi M, Tanaka S. Investigation of coronary artery bypass grafting for a patient with myelodysplastic syndrome. Ann Thorac Cardiovasc Surg. 2001; 7 4
- 8 Bonchek L I, Ullyot D J. Minimally invasive coronary bypass: a dissenting opinion. Circulation. 1998; 98 495-497
Dr. Raif Cavolli
Department of Cardiovascular Surgery
American Hospital
pran SUQU Laprake
Tirana 1026
Albania
eMail: raif.cavolli@gmail.com