Planta Med 2011; 77(2): 175-178
DOI: 10.1055/s-0030-1250176
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Coumarin Derivatives from Gerbera saxatilis

Yin Qiang1 , Yan-Jun Chen1 , Ya Li1 , Jing Zhao2 , Kun Gao1
  • 1State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu, People's Republic of China
  • 2School of Life Sciences, Lanzhou University, Lanzhou, Gansu, People's Republic of China
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Publikationsverlauf

received March 25, 2010 revised June 23, 2010

accepted July 1, 2010

Publikationsdatum:
28. Juli 2010 (online)

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Abstract

Phytochemical investigation of Gerbera saxatilis (Astraceae) afforded three new coumarin derivatives 13 and a known coumarin 4. Compounds 1 and 2 represent the first examples of the natural occurrence of the novel polycyclic pyrano[3-2c]coumarin carbon skeleton. The structures of compounds 14 were characterized based on extensive spectroscopic analyses as well as comparison to the spectroscopic data reported. The structures of compounds 1 and 3 were further confirmed by X‐ray data analyses. The cytotoxic activity of compounds 14 was evaluated against selected cancer cell lines, including human leukemia cell (HL-60), human hepatoma cell (SMMC-7721), and human cervical carcinoma cell (HeLa) lines.

References

Prof. Kun Gao

State Key Laboratory of Applied Organic Chemistry
College of Chemistry and Chemical Engineering
Lanzhou University

Tian Shui Nan Road 222

Lanzhou 730000

People's Republic of China

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Fax: + 86 93 18 91 25 82

eMail: npchem@lzu.edu.cn