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Planta Med 2010; 76(17): 2036-2047
DOI: 10.1055/s-0030-1250450
Traditional Chinese Medicine
Reviews
© Georg Thieme Verlag KG Stuttgart · New York

Systems Biology-Based Diagnostic Principles as Pillars of the Bridge between Chinese and Western Medicine

Jan van der Greef1 , 2 , 3 , 5 [*] , Herman van Wietmarschen1 , 3 [*] , Jan Schroën1 [*] , Mei Wang1 , 5 , Thomas Hankemeier1 , 3 , Guowang Xu1 , 4
  • 1Sino-Dutch Centre for Preventive and Personalized Medicine, Zeist, The Netherlands
  • 2TNO Quality of Life, Zeist, The Netherlands
  • 3Leiden University, Netherlands Metabolomics Center, Division of Analytical Biosciences, Leiden, The Netherlands
  • 4CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, People's Republic of China
  • 5SU BioMedicine, Zeist, The Netherlands
Weitere Informationen

Publikationsverlauf

received February 5, 2010 revised Sept. 20, 2010

accepted Sept. 21, 2010

Publikationsdatum:
26. Oktober 2010 (online)

Auch verfügbar auf
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Abstract

Innovative systems approaches to develop medicine and health care are emerging from the integration of Chinese and Western medicine strategies, philosophies and practices. The two medical systems are highly complementary as the reductionist aspects of Western medicine are favourable in acute disease situations and the holistic aspects of Chinese medicine offer more opportunities in chronic conditions and for prevention. In this article we argue that diagnosis plays a key role in building the bridge between Chinese and Western medicine. Recent advances in the study of health, healing, placebo effects and patient-physician interactions will be discussed pointing out the development of a system-based diagnosis. Especially, a system biology-based diagnosis can be used to capture phenotype information, leading towards a scientific basis for a more refined patient characterization, new diagnostic tools and personalized heath strategies. Subtyping of rheumatoid arthritis patients based on Chinese diagnostic principles is discussed as an example. New insights from this process of integrating Western and Chinese medicine will pave the way for a patient-centred health care ecosystem.

Key words

personalized medicine - Chinese medicine - diagnosis - systems biology - rheumatoid arthritis - metabolomics - phenotyping - targeted care

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1 Each of these authors has equally contributed to this paper.

Jan van der Greef

TNO Quality of Life

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