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Planta Med 2011; 77(7): 733-735
DOI: 10.1055/s-0030-1250526
Biological and Pharmacological Activity
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Antileishmanial Sesquiterpenes from the Brazilian Red Alga Laurencia dendroidea

Fernanda Lacerda da Silva Machado1 , 2 , Wallace Pacienza-Lima3 , Bartira Rossi-Bergmann3 , Lísia Mônica de Souza Gestinari2 , Mutue T. Fujii4 , Joel Campos de Paula5 , Sônia Soares Costa6 , Norberto Peporine Lopes7 , Carlos Roland Kaiser1 , Angélica Ribeiro Soares1 , 2
  • 1Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
  • 2Núcleo de Estudos em Ecologia e Desenvolvimento Sócio-Ambiental de Macaé, Universidade Federal do Rio de Janeiro, Macaé, RJ, Brazil
  • 3Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
  • 4Instituto de Botânica, São Paulo, SP, Brazil
  • 5Instituto de Biociências, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
  • 6Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
  • 7Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil
Further Information

Publication History

received September 22, 2010 revised October 10, 2010

accepted October 13, 2010

Publication Date:
05 November 2010 (online)

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Abstract

Investigation of the bioactive crude extracts from two populations of the red alga Laurencia dendroidea from the southeastern Brazilian coast led to the identification of five sesquiterpenes: (+)-obtusane (1), a triquinane derivative (2), (−)-elatol (3), obtusol (4), and cartilagineol (5). An antileishmanial bioassay against Leishmania amazonensis was conducted for crude lipophilic extracts and for sesquiterpenes 2, 3, and 4. Compounds 3 and 4 displayed in vitro and in vivo leishmanicidal activity and very low cytotoxicity.

Key words

antileishmanial activity - halogenated sesquiterpenes - Laurencia dendroidea J. Agardh - Rhodomelaceae - Leishmania amazonensis Lainson & Shaw

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Angélica Ribeiro Soares

Núcleo de Estudos em Ecologia e Desenvolvimento Sócio-Ambiental de Macaé
Universidade Federal do Rio de Janeiro

Rua Rotary Club s/n° Bairro São José do Barreto

Macaé 27901-000 RJ

Brazil

Phone: +55 22 27 59 34 31

Fax: +55 22 27 62 93 13

Email: angelica.r.soares@gmail.com

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