Planta Med 2011; 77(7): 742-748
DOI: 10.1055/s-0030-1250550
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Mono- and Sesquiterpenoids, Flavonoids, Lignans, and Other Miscellaneous Compounds of Abies georgei

Xian-Wen Yang1 , 2 , Yong-Li Li1 , Su-Mei Li2 , Yun-Heng Shen1 , Jun-Mian Tian1 , Zhi-Jun Zhu1 , Lin Feng1 , Liang Wu1 , Sheng Lin1 , Ning Wang3 , Yonghong Liu2 , Wei-Dong Zhang1
  • 1Department of Natural Product Chemistry, School of Pharmacy, Second Military University, Shanghai, China
  • 2Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, and RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China
  • 3Luxembourg Public Research Center for Health (CRP-SANTE), Luxembourg
Further Information

Publication History

received June 16, 2010 revised October 16, 2010

accepted October 22, 2010

Publication Date:
23 November 2010 (online)

Abstract

A systematic phytochemical investigation of the aerial parts of Abies georgei yielded nine new and 72 known compounds, including four monoterpenes, four sesquiterpenes, 25 flavonones, 14 lignans, and 34 other chemical constituents. The new compounds included two monoterpenes (1 and 2), two sesquiterpenes (3 and 4), three flavonones (5, 6, and 7), and two other components (8 and 9). Their chemical structures were established on the basis of various spectroscopic data. All the isolates were tested for antitumor and anti-inflammatory activities. The new compound 9,4′-dihydroxy-5,7-dimethoxy-8-methylchalcone (7) demonstrated a moderate antiproliferative effect on QGY-7703 tumor cells (IC50 = 17.6 µg/mL). The known compound isoferulaldehyde (67) exhibited the strongest inhibitory activity against lipopolysaccharide (LPS)-induced NO production in RAW 264.7 macrophages (IC50 = 19.0 µg/mL). Abies georgei may be a significant source of beneficial pharmaceutical compounds.

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Dr. Wei-Dong Zhang

Department of Natural Product Chemistry
School of Pharmacy, Second Military Medical University

325 Guohe Road

Shanghai 200433

China

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