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Planta Med 2011; 77(9): 939-944
DOI: 10.1055/s-0030-1250631
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Antitussive Indole Alkaloids from Kopsia hainanensis

Min-Jia Tan1 , Chun Yin2 , Chun-Ping Tang1 , Chang-Qiang Ke1 , Ge Lin2 , Yang Ye1
  • 1State Key Laboratory of Drug Research & Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China
  • 2School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, P. R. China
Further Information

Publication History

received August 30, 2010 revised Nov. 17, 2010

accepted Nov. 23, 2010

Publication Date:
16 December 2010 (online)

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Abstract

Three new indole alkaloids, named kopsihainins A–C (1–3), and two known compounds, kopsinine (4) and methyl demethoxycarbonylchanofruticosinate (5), were isolated from the stems of Kopsia hainanensis. Their structures were determined using extensive spectroscopic methods. The two main constituents 4 and 5 exhibited significant antitussive activity in a citric acid induced guinea pig cough model. The antitussive effect of 4 was demonstrated to interact with the δ-opioid receptor. This is the first report of antitussive effects of aspidofractinine type and chanofruticosinate type alkaloids.

Key words

Kopsia hainanensis - Apocynaceae - danuphyllin type - aspidofractinine type - chanofruticosinate type - antitussive activity

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Prof. Yang Ye

State Key Laboratory of Drug Research & Natural Products Chemistry Department
Shanghai Institute of Materia Medica
Chinese Academy of Sciences

555 Zu-Chong-Zhi Road, Zhangjiang Hightech Park

Shanghai 201203

P. R. China

Phone: +86 21 50 80 67 26

Fax: +86 21 50 80 67 26

Email: yye@mail.shcnc.ac.cn

Prof. Ge Lin

School of Biomedical Sciences
The Chinese University of Hong Kong

Shatin, N. T.

Hong Kong SAR

P. R. China

Phone: +85 2 26 09 68 24

Fax: +85 2 26 03 51 39

Email: linge@cuhk.edu.hk

    www.thieme-connect.de/ejournals/toc/plantamedica