Antitussive Indole Alkaloids from Kopsia hainanensis

Abstract

Three new indole alkaloids, named kopsihainins A–C (1–3), and two known compounds, kopsinine (4) and methyl demethoxycarbonylchanofruticosinate (5), were isolated from the stems of Kopsia hainanensis. Their structures were determined using extensive spectroscopic methods. The two main constituents 4 and 5 exhibited significant antitussive activity in a citric acid induced guinea pig cough model. The antitussive effect of 4 was demonstrated to interact with the δ-opioid receptor. This is the first report of antitussive effects of aspidofractinine type and chanofruticosinate type alkaloids.

Key words

Kopsia hainanensis - Apocynaceae - danuphyllin type - aspidofractinine type - chanofruticosinate type - antitussive activity

References

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