Abstract
Hoodia gordonii is a spiny succulent plant popularly consumed for its purported anti-obesity effect. Traditionally used by the Khoi-San of South Africa and Namibia as a hunger and thirst suppressant while on long hunting trips, the commercialisation of this plant has been highly controversial due to intellectual property rights and benefit sharing issues, as well as the fact that several prominent pharmaceutical companies involved in its development have withdrawn their interest. Quality control has been the main focus of scientific studies as the supply of H. gordonii plant material is limited due to its sparse geographical distribution, slow maturation rate, need for a permit to cultivate or export material as well as high public demand, contributing to adulteration of a large amount of products. Despite the isolation of numerous steroidal glycosides from H. gordonii, the main focus has been on the pregnane glycoside P57, considered to be the active ingredient and marker molecule to determine quality of raw material and products. Publications based on scientific studies of key aspects such as in vivo biopharmaceutics, the biological activity of all chemical constituents, clinical efficacy, and especially safety are insufficient or completely absent causing great concern as H. gordonii is one of the most widely consumed anti-obesity products of natural origin. This review offers an up-to-date overview of all the current available knowledge pertaining to H. gordonii achieved by systematic analysis of the available literature.
Key words
Hoodia gordonii
- Apocynaceae - appetite suppressant - glycosides - obesity - P57
References
-
1
Glasl S.
Hoodia: A herb used in South African traditional medicine – A potential cure for overweight? Pharmacognostic review of history, composition, health-related claims, scientific evidence and intellectual property rights.
Schweiz Z Ganzheitsmed.
2009;
21
300-306
-
2 World Health Organization (WHO) .Fact sheet no 311. Available at:. http://www.who.int/mediacentre/factsheets/fs311/en/print.html 09/2006 Accessed September 29, 2009
-
3 Van Heerden F R, Vleggaar R, Horak R M, Learmonth R A, Maharaj V, Whittal R D. Pharmaceutical compositions having appetite-suppressant activity. US Patent 6376657 B1. 2002
-
4
Pawar R S, Shukla Y J, Khan S I, Avula B, Khan I A.
New oxypregnane glycosides from appetite suppressant herbal supplement Hoodia gordonii.
Steroids.
2007;
72
524-534
-
5
Pawar R S, Shukla Y J, Khan I A.
New calogenin glycosides from Hoodia gordonii.
Steroids.
2007;
72
881-891
-
6
Dall'Acqua S, Innocenti G.
Steroidal glycosides from Hoodia gordonii.
Steroids.
2007;
72
559-568
-
7 Abrahamse S L, Povey K J, Rees D D. Appetite suppressant compositions. US Patent 0207227 A1. 2007
-
8
Shukla Y J, Pawar R S, Ding Y, Li X-C, Ferreira D, Khan I A.
Pregnane glycosides from Hoodia gordonii.
Phytochemistry.
2009;
70
675-683
-
9
Avula B, Wang Y H, Pawar R S, Shukla Y J, Schaneberg B, Khan I A.
Determination of the appetite suppressant P57 in Hoodia gordonii plant extracts and dietary supplements by liquid chromatography/electrospray ionization mass spectrometry (LC-MSD-TOF) and LC-UV methods.
J AOAC Int.
2006;
89
606-611
-
10 Van Wyk B-E, Wink M. Medicinal plants of the world. Pretoria; Briza Publications 2004: 171
-
11 Bruyns P V. Stapeliads of Southern Africa and Madagascar, Volume 1. Pretoria; Umdaus Press 2005
-
12 Olivier I.
Hoodia gordonii (Masson) Sweet ex Decne. Available at. http://www.plantzafrica.com/planthij/hoodgord.htm Accessed February 5, 2008
-
13
Van Heerden F.
Hoodia gordonii: A natural appetite suppressant.
J Ethnopharmacol.
2008;
119
434-437
-
14
Holt S, Taylor T V.
Hoodia gordonii: an overview of biological and botanical characteristics: Part 1.
Townsend Lett.
2006;
280
104-113
-
15 Van Wyk B-E, Gericke N. People's plants. Pretoria; Briza Publications 2000: 70
-
16
Van Heerden F R, Horak R M, Maharaj V J, Vleggaar R, Senabe J V, Gunning P J.
An appetite suppressant from Hoodia species.
Phytochemistry.
2007;
68
2545-2553
-
17 Foden W. Information document on trade in Hoodia gordonii and other Hoodia species. Available at. http://www.plantzafrica.com/planthij/hoodia.htm Accessed June 29, 2010
-
18 Wynberg R, Schroeder D, Chennels R. Indigenous peoples, consent and benefit sharing. Lessons from the San-Hoodia case. London; Springer Publications 2009 11-26 89-121
-
19
Avula B, Wang Y-H, Pawar R S, Shukla Y J, Smillie T J, Khan I A.
A rapid method for chemical fingerprint analysis of Hoodia species, related genera, and dietary supplements using UPLC-UV-MS.
J Pharm Biomed Anal.
2008;
48
722-731
-
20
Tulp O L, Harbi N.
Effect of Hoodia plant on food intake and body weight in lean and obese LA/Ntul//cp-rats.
FASEB J.
2001;
15
A404
-
21
Tulp O L, Harbi N.
Effect of Hoodia plant on weight loss in congenic obese LA/Ntul//-cp rats.
FASEB J.
2002;
16
A654
-
22
MacLean D B, Luo L-G.
Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside.
Brain Res.
2004;
1020
1-11
-
23
Mohlapo T D, Ng'ambi J W, Norris D, Malatje M M.
Effect of Hoodia gordonii meal supplementation at finisher stage on productivity and carcass characteristics of Ross 308 broiler chickens.
Trop Anim Health Prod.
2009;
41
1591-1596
-
24
Holt S, Taylor T V.
Hoodia gordonii: Part 2: separating science from speculation.
Townsend Lett.
2006;
281
99-104
-
25 Hakkinen J, Horak R M, Maharaj V. Gastric acid secretion. US Patent 0079233 A1. 2005
-
26
Madgula V L M, Avula B, Pawar R S, Shukla Y J, Khan I A, Walker L A, Khan S I.
Characterization of in vitro pharmacokinetic properties of hoodigogenin A from Hoodia gordonii.
Planta Med.
2010;
76
62-69
-
27 Rubin I D, Bindra J S, Cawthorne M A. Extracts, compounds and pharmaceutical compositions having anti-diabetic activity and their use. US Patent 0159779 A1. 2006
-
28
Madgula V L M, Avula B, Pawar R S, Shukla Y J, Khan I A, Walker L A, Khan S I.
In vitro metabolic stability and intestinal transport of P57AS3 (P57) from Hoodia gordonii and its interaction with drug metabolizing enzymes.
Planta Med.
2008;
74
1269-1275
-
29
Madgula V L M, Ashfaq M K, Wang Y-H, Avula B, Khan I A, Walker L A, Khan S I.
Bioavailability, pharmacokinetics, and tissue distribution of the oxypregnane steroidal glycoside P57AS3 (P57) from Hoodia gordonii in mouse model.
Planta Med.
2010;
76
1582-1586
-
30
Menniti-Ippolito F, Mazzanti G, Santuccio C, Moro P A, Calapai G, Firenzuoli F, Valeri A, Raschetti R.
Surveillance of suspected adverse reactions to natural health products in Italy.
Pharmacoepidemiol Drug Saf.
2008;
17
626-635
-
31
Homoud M K.
The sale of weight-loss supplements on the Internet: A lurking health crisis waiting to strike.
Heart Rhythm.
2009;
6
658-662
-
32
Janssen H-G, Swindells C, Gunning P, Wang W, Grün C, Mahabir K, Maharaj V J, Apps P J.
Quantification of appetite suppressing steroid glycosides from Hoodia gordonii in dried plant material, purified extracts and food products using HPLC-UV and HPLC-MS methods.
Anal Chim Acta.
2008;
617
200-207
-
33
Avula B, Wang Y H, Pawar R S, Shukla Y J, Khan I A.
Chemical fingerprinting of Hoodia species and related genera: chemical analysis of oxypregnane glycosides using high-performance liquid chromatography with UV detection in Hoodia gordonii.
J AOAC Int.
2007;
90
1526-1531
-
34
Widmer V, Reich E, DeBatt A.
Validated HPTLC method for identification of Hoodia gordonii.
J Planar Chromatogr Mod TLC.
2008;
21
21-26
-
35
Rumalla C S, Avula B, Shukla Y J, Wang Y-H, Pawar R S, Smillie T J, Khan I A.
Chemical fingerprint of Hoodia species, dietary supplements, and related genera by using HPTLC.
J Sep Sci.
2008;
31
3959-3964
-
36
Vermaak I, Hamman J H, Viljoen A M.
High performance thin layer chromatography as a method to authenticate Hoodia gordonii raw material and products.
S Afr J Bot.
2010;
76
119-124
-
37
Vermaak I, Hamman J H, Viljoen A M.
A rapid spectroscopic method for quantification of P57 in Hoodia gordonii raw material.
Food Chem.
2010;
120
940-944
-
38
Vermaak I, Viljoen A M, Hamman J H, Baranska M.
The potential application of FT-Raman spectroscopy for the quantification and mapping of the steroidal glycoside P57 in Hoodia gordonii.
Phytochem Lett.
2010;
3
156-160
-
39
Joshi V, Techen N, Scheffler B E, Khan I A.
Identification and differentiation between Hoodia gordonii (Masson) Sweet ex Decne., Opuntia ficus indica (L.) P. Miller, and related Hoodia species using microscopy and PCR.
J Herbs Spices Med Plants.
2009;
15
253-264
-
40
Marston A.
Role of advances in chromatographic techniques in phytochemistry.
Phytochemistry.
2007;
68
2785-2797
-
41
Moros J, Garrigues S, De la Guardia M.
Vibrational spectroscopy provides a green tool for multi-component analysis.
Trends Anal Chem.
2010;
29
578-591
Alvaro M. Viljoen
Department of Pharmaceutical Sciences
Faculty of Science, Tshwane University of Technology
Private Bag X680
Pretoria 0001
South Africa
Telefon: +27 1 23 82 63 60
Fax: +27 1 23 82 62 43
eMail: viljoenam@tut.ac.za
