Planta Med 2010; 76 - P47
DOI: 10.1055/s-0030-1251809

Rearranged Cycloartanol Glycosides from Sutherlandia frutescens

X Fu 1, XC Li 2, TJ Smillie 2, IA Khan 1, 2
  • 1Department of Pharmacognosy, University of Mississippi, MS 38677, USA
  • 2National Center for Natural Products Research, University of Mississippi, MS 38677, USA

Two novel rearranged cycloartanol glycosides, sutherlandiosides E (1) and F (2), and other two new cycloartanol glycosides, sutherlandiosides G (3) and H (4) were isolated from Sutherlandia frutescens. Their structures were elucidated by spectroscopic methods. The aglycones of 1 and 2 possess a rearranged five- and seven-membered A/B-ring system. This is the first report of the hexadecahydro-1-H-indeno[5,4-f] azulene ring system in nature.

Fig.1

Acknowledgements: The authors thank The International Center for Indigenous Phytotherapy Studies for providing plant material, Dr. Bharathi Avula for MS data, Dr. Yan-Hong Wang for HPLC assistances, Mr. Frank T. Wiggers for the assistance in obtaining NMR spectra. This work is supported in part by „The International Center for Indigenous Phytotherapy Studies“ funded by NCCAM, grant number 5U19 AT 003264 and the USDA Agricultural Research Service Specific Cooperative Agreement No. 58–6408–2-0009. References: [1] Fu X, Li X, et al. (2008)J Nat Prod 71: 1749–1753.