Planta Med 2010; 76 - P65
DOI: 10.1055/s-0030-1251827

Polybrominated Phenolics from Lendenfeldia dendyi with Antibacterial, Antifungal and Anti-HIV Activities

MM Radwan 1, MR Jacob 1, R Schinazi 2, KM Ishfaq 1, FR Fronczek 3, SA Ross 1, 4
  • 1National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA
  • 2Veterans Affair Medical Center, Atlanta, GA 30033, USA
  • 3Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA
  • 4Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS 38677, USA

Bioassay guided fractionation of the marine sponge Ledenfeldia denyi resulted in the isolation of four polybrominated diphenyl ethers (1–4). The structures of the isolated compounds were determined using spectroscopic methods (1D and 2D NMR). The structure of compounds 1 and 2 were confirmed by X-ray analysis. Antimicrobial testing [1] of the isolated compounds indicated that they displayed significant antibacterial activity against methicillin-resistant Staphylococcus aureus with IC50S of 0.1–0.6µg/mL., and potent antifungal activity against Cryptococcus neoformans (IC50S of 0.15–1.5µg/mL). Compounds 1 and 2 displayed mild anti-HIV activity in Human PBM cells [2] with EC50 of 35.9 and 10.9µM, respectively.

Fig.1

Acknowledgments: We are thankful to Dr. Bharathi Avula, and Ms Marsh Wright, National Center for Natural Products Research for assistance with the HRESIMS, and antimicrobial assays respectively. References: [1] Radwan MM, Manly SP, Ross SA (2007) Nat Prod Comm 2: 901–904. [2] Schinazi, et al. (1990) Antimicrob Agents Chemother 34: 1061–1067.