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DOI: 10.1055/s-0030-1253290
© Georg Thieme Verlag KG Stuttgart ˙ New York
Therapie von chronisch Nierenkranken ‐ Welche Rolle spielt die selektive VDR-Aktivierung?
Publication History
Publication Date:
06 April 2010 (online)
Ende November hielt Prof. Kamyar Kalantar-Zadeh, Los Angeles (USA), bei der Herbsttagung des Colloquiums nephrologicum Thüringen einen Vortrag über selektive VDR-Aktivierung (sVDRA), der auf viel Interesse stieß und lebhaft diskutiert wurde. Denn mit fortschreitender chronischer Nierenerkrankung (CKD) sind Hyperphosphatämie, Hypokalzämie und Mangel an 1,25-Vitamin-D3 die Hauptfaktoren für die Entwicklung des sekundären Hyperparathyreoidismus (sHPT). Kalantar-Zadeh gab einen ganz aktuellen Überblick über den Wissensstand zum Thema sHPT und zur Bedeutung der selektiven VDR-Aktivierung in der Therapie von CKD-Patienten.
Literatur
- 01 Kovesdy C P, Ahmadzadeh S , Anderson J E, Kalantar-Zadeh K . Association of activated vitamin D treatment and mortality in chronic kidney disease. Arch Intern Med. 2008; 168 397-403
- 02 Shinaberger C S, Kopple J D, Kovesdy C P, et al . Ratio of paricalcitol dosage to serum parathyroid hormone level and survival in maintenance hemodialysis patients. Clin J Am Soc Nephrol. 2008; 3 1769-1776
- 03 Regidor D L, Kovesdy C P, Mehrotra R , et al . Serum alkaline phosphatase predicts mortality among maintenance hemodialysis patients. J Am Soc Nephrol. 2008; 19 2193-2203
- 04 Shantouf F , Kovesdy C P, Kim Y , et al . Association of serum alkaline phosphatase with coronary artery calcification in maintenance hemodialysis patients. Clin J Am Soc Nephrol. 2009; 4 1106-1114
- 05 Kalantar-Zadeh K , Kovesdy C P. Clinical outcomes with active versus nutritional vitamin D compounds in chronic kidney disease. Clin J Am Soc Nephrol. 2009; 4 1529-1539
- 06 Dukkipati R , Kalantar-Zadeh K , Kopple J D. Is there a role for intradialytic parenteral nutrition? A review of the evidence. Am J Kidney Dis. 2010; 55 352-364
- 07 Teng M , Wolf M , Lowrie E , et al . Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy. N Eng J Med. 2003; 349 446-456
- 08 Teng M , Wolf M , Ofshun M N, et al . Activated injectable vitamin D and hemodialysis survival: a historical cohort study. J Am Soc Nephrol. 2005; 16 1115-1125
- 09 Lund R J, Andress D L, Amdahl M , et al . Absorption in Hemodialysis Patients. Am J Nephrol. 2010; 31 165-170
- 10 Mizobuchi M , Finch J L, Martin D R, et al . Differential effects of vitamin D receptor activators on vascular calcification in uremic rats. Kidney Int. 2007; 72 709-715
- 11 Wu-Wong J R, Noonan W , Ma J , et al . Role of phosphorus and vitamin D analogs in the pathogenesis of vascular calcification. J Pharmacol Exp Ther. 2006; 318 90-98
- 12 Henley C , Colloton M , Cattley R C, et al . 1,25-Dihydroxyvitamin D3 but not cinacalcet HCl treatment mediates aortic calcification in a rat model of secondary hyperparathyroidism. Nephrol Dial Transplant. 2005; 20 1370-1377
- 13 Agarwal R , Acharya M , Tian J , et al . Antiproteinuric effect of oral paricalcitol in chronic kidney disease. Kidney Int. 2005; 68 2823-2828
- 14 Alborzi P , Patel N A, Peterson C , et al . Paricalcitol reduces albuminuria and inflammation in chronic kidney disease. A randomized double-blind pilot trial. Hypertension. 2008; 52 249-255
- 15 de Zeeuw D , Agarwal R , Parving H , et al . A study of paricalcitol capsules on reducing albuminuria in type 2 diabetic nephropathy being treated with renin-angiotensin system inhibitors (NCT00421733). Im Internet:. http://www.clinicaltrials.gov 08.03.2010
01 Selective Vitamin D Receptor (VDR) Activator for Albuminuria Lowering (VITAL) Study in Type 2 Diabetic Nephropathy