Outcomes of Severe COPD Exacerbations Requiring Hospitalization

Praveen R Chenna; David M Mannino

doi:10.1055/s-0030-1254069

Seminars in Respiratory and Critical Care Medicine, Table of Contents

Semin Respir Crit Care Med 2010; 31(3): 286-294
DOI: 10.1055/s-0030-1254069

Outcomes of Severe COPD Exacerbations Requiring Hospitalization

Praveen R. Chenna¹ , David M. Mannino¹ ^, ²

¹Division of Pulmonary and Critical Care Medicine, University of Kentucky Medical Center, Lexington, Kentucky
²Department of Preventive Medicine and Environmental Health, University of Kentucky Medical Center, Lexington, Kentucky

Abstract

ABSTRACT

Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are important events in the lives of patients with COPD. While several definitions exist for AECOPD, exacerbations that result in a hospitalization would nearly always be considered severe. On average, exacerbation rates are ∼1 to 2 per patient-year with COPD hospitalizations averaging ∼0.1 to 0.2 per patient-year. Many risk factors, some of which are modifiable, such as patient adherence to therapy, pulmonary rehabilitation, and type of medication used, influence the rate of AECOPD. Severe AECOPD that result in hospitalization often lead to several adverse affects, including decreased quality of life, diminished lung function, weakness, reexacerbations/rehospitalization, cardiopulmonary complications, and death. Preventing severe AECOPD and their sequelae is a critical component in treating our patients with COPD.

KEYWORDS

COPD - exacerbations - outcomes - hospitalization - epidemiology

Full Text

References

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David M ManninoM.D.

Division of Pulmonary and Critical Care Medicine, University of Kentucky Medical Center

740 S. Limestone, L–548, Lexington, KY 40536

Email: dmannino@uky.edu