Endoscopic diagnosis and treatment of upper gastrointestinal tumors

Introduction

At the 2010 Digestive Disease Week (DDW; 1 – 5 May 2010, New Orleans, Louisiana, USA), a substantial amount of research on advanced endoscopic techniques for diagnosing and treating tumors of the upper gastrointestinal tract was presented. This review discusses the final or interim findings from 12 selected papers that focused on new developments in the diagnosis of cancer and precancerous lesions [1] [2], endotherapy for early cancer and its precursors [3] [4] [5] [6] [7] [8] [9], and endotherapy for advanced cancer [10] [11] [12]. Issues related to Barrett’s dysplasia and cancer are covered in a separate report that appears elsewhere in the journal [13].

References

• 1 Kim J S, Nam K W, Cho Y K. et al . The usefulness of tumor margin marking using autofluorescence endoscopy in endoscopic submucosal dissection.  Gastrointest Endosc. 2010;  71 AB206
• 2 Shahid M W, Buchner A M, Gomez V. et al . Role of probe-based confocal laser endomicroscopy (pCLE) in detection of dysplasia in duodenal polyps.  Gastrointest Endosc. 2010;  71 AB199
• 3 Bergman J, Fleischer D E, Yueming Z. et al . First prospective study on endoscopic radiofrequency ablation of moderate and high-grade intraepithelial squamous neoplasia and early squamous cell cancer of the esophagus.  Gastrointest Endosc. 2010;  71 AB126-AB127
• 4 Van Vilsteren F G, Herrero L A, Pouw R E. et al . A pilot trial of endoscopic radiofrequency ablation for the eradication of esophageal squamous intraepithelial neoplasia and early squamous cell carcinoma limited to the mucosa.  Gastroenterology. 2010;  138 Suppl 1 S-863
• 5 Satake H, Yano T, Minashi K. et al . Long-term results of endoscopic resection (ER) for patients with superficial head and neck squamous cell carcinoma (HNSCC).  Gastrointest Endosc. 2010;  71 AB124
• 6 Kitamura Y, Oyama T. Outcome of endoscopic treatment for superficial pharyngeal squamous cell carcinoma.  Gastrointest Endosc. 2010;  71 AB125
• 7 Takao T, Takizawa K, Tanaka M. risk factors and clinical outcomes of gastric perforation induced by endoscopic submucosal dissection (ESD) for gastric neoplasms.  Gastrointest Endosc. 2010;  71 AB105
• 8 Ohki T, Yamato M, Ota M. et al . Advances in cell sheet technology to prevent post-esophageal ESD stenosis: clinical research results.  Gastrointest Endosc. 2010;  71 AB125
• 9 Lee B I, Kim B W, Choi H. et al . Effect of routine mucosal closure after endoscopic submucosal dissection for gastric neoplasms: a randomized controlled trial.  Gastrointest Endosc. 2010;  71 AB105
• 10 Yano T, Muto M, Minashi K. et al . Phase II study of photodynamic therapy (PDT) for local failure after chemoradiotherapy (CRT) in patients with esophageal squamous cell carcinoma (ESCC).  Gastroenterology. 2010;  138 S758-S759
• 11 Nagahisa E, Yano T, Minashi K. et al . Photodynamic therapy for local failure after chemoradiotherapy for patients with unresectable locally advanced esophageal squamous cell carcinoma.  Gastrointest Endosc. 2010;  71 AB237
• 12 Van Heel N, Haringsma J, Spaander M. Efficacy of esophageal metal stents for the relief of malignant dysphagia due to extrinsic compression in a large prospective series.  Gastrointest Endosc. 2010;  71 AB177-AB178
• 13 di Pietro M. Barrett’s esophagus and reflux disease.  Endoscopy. 2010;  42 910-915
• 14 Lee J H, Cho J Y, Choi M G. et al . Usefulness of autofluorescence imaging for estimating the extent of gastric neoplastic lesions: a prospective multicenter study.  Gut Liver. 2008;  2 174-179
• 15 Bisschops R, Bergman J. Probe-based confocal laser endomicroscopy: scientific toy or clinical tool?.  Endoscopy. 2010;  42 487-489
• 16 Neumann H, Kiesslich R, Wallace M B, Neurath M F. Confocal laser endomicroscopy: technical advances and clinical applications.  Gastroenterology. 2010;  139 388-392.e2
• 17 Shaheen N J, Sharma P, Overholt B F. et al . Radiofrequency ablation in Barrett’s esophagus with dysplasia.  N Engl J Med. 2009;  360 2277-2288
• 18 Zhang Y M, Bergman J J, Weusten B. et al . Radiofrequency ablation for early esophageal squamous cell neoplasia.  Endoscopy. 2010;  42 327-333
• 19 Muto M, Minashi K, Yano T. et al . Early detection of superficial squamous cell carcinoma in the head and neck region and esophagus by narrow band imaging: a multicenter randomized controlled trial.  J Clin Oncol. 2010;  28 1566-1572
• 20 Suzuki H, Saito Y, Oda I. et al . Feasibility of endoscopic mucosal resection for superficial pharyngeal cancer: a minimally invasive treatment.  Endoscopy. 2010;  42 1-7
• 21 Ikehara H, Gotoda T, Ono H. et al . Gastric perforation during endoscopic resection for gastric carcinoma and the risk of peritoneal dissemination.  Br J Surg. 2007;  94 992-995
• 22 Ono S, Fujishiro M, Niimi K. et al . Predictors of postoperative stricture after esophageal endoscopic submucosal dissection for superficial squamous cell neoplasms.  Endoscopy. 2009;  41 661-665
• 23 Ohki T, Yamato M, Murakami D. et al . Treatment of oesophageal ulcerations using endoscopic transplantation of tissue-engineered autologous oral mucosal epithelial cell sheets in a canine model.  Gut. 2006;  55 1704-1710
• 24 Matsushita M, Danbara N, Omiya M. et al . Is closure of large mucosal defects after endoscopic mucosal resection and endoscopic submucosal dissection truly needed?.  Endoscopy. 2008;  40 706; author reply 707
• 25 Cooper J S, Guo M D, Herskovic A. et al . Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology Group.  JAMA. 1999;  281 1623-1627
• 26 Yano T, Muto M, Minashi K. et al . Photodynamic therapy as salvage treatment for local failures after definitive chemoradiotherapy for esophageal cancer.  Gastrointest Endosc. 2005;  62 31-36
• 27 Yano T, Muto M, Hattori S. et al . Long-term results of salvage endoscopic mucosal resection in patients with local failure after definitive chemoradiotherapy for esophageal squamous cell carcinoma.  Endoscopy. 2008;  40 717-721
• 28 Van Heel N C, Haringsma J, Spaander M C. et al . Esophageal stents for the relief of malignant dysphagia due to extrinsic compression.  Endoscopy. 2010;  42 536-540