RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000002.xml
Aktuelle Dermatologie 2011; 37(8/09): 317-332
DOI: 10.1055/s-0030-1256728
DOI: 10.1055/s-0030-1256728
Fort- und Weiterbildung
© Georg Thieme Verlag KG Stuttgart · New York
Graft-versus-Host-Erkrankung der Haut
Graft-versus-Host-Disease of the SkinWeitere Informationen
Publikationsverlauf
Publikationsdatum:
30. August 2011 (online)

Lernziele
Kenntnisse über:
Klassifikation und Grading der Graft-versus-Host-Erkrankung (GvHD) Organmanifestationen Klinik der kutanen GvHD Diagnostik der kutanen GvHD nach NIH-Konsensus Therapie der kutanen GvHD
Literatur
- 1 Hertenstein B, Ganser A. Knochenmarktransplantation. Internist. 2004; 45 1261-1267
-
2 Deutsches Register für Stammzelltransplantation. Jahresbericht 2009. Im Internet: http://www.drst.de/jb.html Stand 11.08.2010
- 3 Buchholz S, Ganser A. Hämatopoetische Stammzelltransplantation. Internist. 2009; 50 572-580
- 4 Billingham R E. The biology of graft-versus-host reactions. Harvey Lect. 1966–1967; 62 21-78
- 5 Ringdén O, Karlsson H, Olsson R et al. The allogeneic graft-versus-cancer effect. Br J Haematol. 2009; 147 614-633
- 6 Ferrara J LM, Levine J E, Reddy P et al. Graft-versus-host disease. Lancet. 2009; 373 1550-1561
- 7 Shlomchik W D. Graft-versus-host disease. Nat Rev Immunol. 2007; 7 340-352
- 8 Beelen D W, Haralambie E, Brandt H et al. Evidence that sustained growth suppression of intestinal anaerobic bacteria reduces the risk of acute graft-versus-host disease after sibling marrow transplantation. Blood. 1992; 80 2668-2676
- 9 Penack O, Holler E, van den Brink M R. Graft-versus-host disease: regulation by microbe-associated molecules and innate immune receptors. Blood. 2010; 115 1865-1872
- 10 Leung A Y, Kwong Y L. Haematopoetic stem cell transplantation: current concepts and novel therapeutic strategies. Br Med Bull. 2010; 93 85-103
- 11 Ball L M, Egeler R M EBMT Paediatric Working Party. Acute GvHD: pathogenesis and classification. Bone Marrow Transplant. 2008; 41 (Suppl. 2) 58-64
- 12 Martin P J. Biology of chronic graft-versus-host disease: implications for a future therapeutic approach. Keio J Med. 2008; 57 177-183
- 13 Lee J W, Deeg J H. Prevention of chronic GVHD. Best Pract Res Clin Haematol. 2008; 21 259-270
- 14 Shimabukuro-Vornhagen A, Hallek M J, Storb R F et al. The role of B cells in the pathogenesis of graft-versus-host disease. Blood. 2009; 114 4919-4927
- 15 Svegliati S, Olivieri A, Campelli N et al. Stimulatory autoantibodies to PDGF receptor in patients with extensive chronic graft-versus-host disease. Blood. 2007; 110 237-241
- 16 Kim S J, Lee J W, Jung C W et al. Weekly rituximab followed by monthly rituximab treatment for steroid-refractory chronic graft-versus-host disease: results from a prospective, multicenter, phase II study. Haematologica. 2010; 95 1935-1942
- 17 Rieger K, Loddenkemper C, Maul J et al. Mucosal FOXP3+ regulatory T cells are numerically deficient in acute and chronic GvHD. Blood. 2006; 107 1717-1723
- 18 Hoffmann P, Ermann J, Edinger M et al. Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med. 2002; 196 389-399
- 19 Pidala J, Anasetti C. Can antigen-specific regulatory T cells protect against graft versus host disease and spare anti-malignancy alloresponse?. Haematologica. 2010; 95 660-665
- 20 Filipovich A H, Weisdorf D, Pavletic S et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant. 2005; 11 945-956
- 21 Glucksberg H, Storb R, Fefer A et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation. 1974; 18 295-304
- 22 Przepiorka D, Weisdorf D, Martin P et al. 1994 Consensus Conference on Acute GVHD Grading. Bone Marrow Transplant. 1995; 15 825-828
- 23 Cahn J Y, Klein J P, Lee S J et al. Prospective evaluation of 2 acute graft-versus-host (GVHD) grading systems: a joint Société Française de Greffe de Moëlle et Thérapie Cellulaire (SFGM-TC), Dana Farber Cancer Institute (DFCI), and International Bone Marrow Transplant Registry (IBMTR) prospective study. Blood. 2005; 106 1495-1500
- 24 Socié G, Stone J V, Wingard J R et al. Long-term survival and late deaths after allogeneic bone marrow transplantation. Late Effects Working Committee of the International Bone Marrow Transplant Registry. N Engl J Med. 1999; 341 14-21
- 25 Joseph R W, Couriel D R, Komanduri K V. Chronic Graft-Versus-Host Disease After Allogeneic Stem Cell Transplantation: Challenges in Prevention, Science, and Supportive Care. J Support Oncol. 2008; 6 361-372
- 26 Lee S J, Flowers M ED. Recognizing and Managing Chronic Graft-Versus-Host Disease. Hematology Am Soc Hematol Educ Program. 2008; 1 134-141
- 27 Baker K S, Fraser C J. Quality of life and recovery after graft-versus-host disease. Best Pract Res Clin Haematol. 2008; 21 333-341
- 28 Hymes S R, Turner M L, Champlin R E et al. Cutaneous Manifestations of Chronic Graft-versus-Host Disease. Biol Blood Marrow Transplant. 2006; 12 1101-1113
- 29 Lerner K G, Kao G F, Storb R et al. Histopathology of graft-versus-host reaction (GVHR) in human recipients of marrow from HL-A matched sibling donors. Transplant Proc. 1974; 6 367-371
- 30 Shulman H M, Kleiner D, Lee S J et al. Histopathologic diagnosis of chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. Pathology Working Group Report. Biol Blood Marrow Transplant. 2006; 12 31-47
- 31 Apperley J, Carreras E, Gluckman E et al. eds. The EBMT-ESH Handbook on Haematopoietic stem cell transplantation. 5th ed. 2008 Im Internet: http://www.ebmt.org/EBMT_Handbook.html
- 32 Deeg H J. How I treat refractory acute GVHD. Blood. 2007; 109 4119-4126
- 33 Paczesny S, Choi S W, Ferrara J L. Acute graft-versus-host disease: new treatment strategies. Curr Opin Hematol. 2009; 16 427-436
- 34 Furlong T, Leisenring W, Storb R et al. Psoralen and Ultraviolet A Irradiation (PUVA) as Therapy for Steroid-Resistant Cutaneous Acute Graft-versus-Host Disease. Biol Blood Marrow Transplant. 2002; 8 206-212
- 35 Schlaak M, Schwind S, Wetzig T et al. UVA (UVA-1) therapy for the treatment of acute GVHD of the skin. Bone Marrow Transplant. 2010; 45 1741-1748
- 36 Greinix H T, Knobler R M, Worel N et al. The effect of intensified extracorporeal photochemotherapy on long-term survival in patients with severe acute graft-versus-host disease. Haematologica. 2006; 91 405-408
- 37 Greinix H T, Worel N, Knobler R. Role of Extracorporeal Photopheresis (ECP) in treatment of steroidrefractory acute graft-versus-host disease. Biol Blood Marrow Transplant. 2010; 16 1747-1748
- 38 Jagasia M, Giglia J, Chinratanalab W et al. Incidence and outcome of chronic graft-versus-host disease using National Institutes of Health consensus criteria. Biol Blood Marrow Transplant. 2007; 13 1207-1215
- 39 Cho B S, Min C K, Eom K S et al. Feasibility of NIH consensus criteria for chronic graft-versus-host disease. Leukemia. 2009; 23 78-84
- 40 Wolff D, Gerbitz A, Ayuk F et al. Consensus conference on clinical practice in chronic graft-versus-host disease (GVHD): First-line and topical treatment of chronic GVHD. Biol Blood Marrow Transplant. 2010; 16 1611-1628
- 41 Elad S, Or R, Resnick I, Shapira M Y. Topical tacrolimus – a novel treatment alternative for cutaneous chronic graft-versus-host disease. Transpl Int. 2003; 16 665-670
- 42 Choi C J, Nghiem P. Tacrolimus ointment in the treatment of chronic cutaneous graft-vs-host disease: a case series of 18 patients. Arch Dermatol. 2001; 137 1202-1206
- 43 Koc S, Leisenring W, Flowers M E et al. Therapy for chronic graft-versus-host disease: a randomized trial comparing cyclosporine plus prednisone versus prednisone alone. Blood. 2002; 100 48-51
- 44 Wolff D, Schleuning M, von Harsdorf S et al. Consensus conference on clinical practice in chronic GVHD: Second-Line Treatment of chronic Graft-versus-Host Disease. Biol Blood Marrow Transplant. 2011; 17 1-17
- 45 Couriel D R, Hosing C, Saliba R et al. Extracorporeal photochemotherapy for the treatment of steroid-resistant chronic GVHD. Blood. 2006; 107 3074-3080
- 46 Flowers M E, Apperley J F, van Besien K et al. A multicenter prospective phase 2 randomized study of extracorporeal photopheresis for treatment of chronic graft-versus-host disease. Blood. 2008; 112 2667-2674
PD Dr. Uwe Hillen
Klinik für Dermatologie
Universitätsklinikum Essen
Hufelandstr. 55
45147 Essen
eMail: uwe.hillen@uk-essen.de